RT info:eu-repo/semantics/article T1 Tackling Post-COVID-19 Rehabilitation Challenges: A Pilot Clinical Trial Investigating the Role of Robotic-Assisted Hand Rehabilitation A1 Cisnal De La Rica, Ana A1 Alonso Linaje, Gonzalo A1 Fraile Marinero, Juan Carlos A1 Pérez Turiel, Javier A1 Álvarez, Pablo A1 Martinez, Socorro K1 case report K1 COVID-19 K1 musculoskeletal sequalae K1 physical rehabilitation K1 robotic therapy AB Prolonged hospitalization in severe COVID-19 cases can lead to substantial muscle loss and functional deterioration. While rehabilitation is essential, conventional approaches face capacity challenges. Therefore, evaluating the effectiveness of robotic-assisted rehabilitation for patients with post-COVID-19 fatigue syndrome to enhance both motor function and overall recovery holds paramount significance. Our objective is to assess the effectiveness of rehabilitation in post-COVID-19 patients with upper extremity impairment through the utilization of a hand exoskeleton-based robotic system. Methods: A total of 13 participants experiencing acute or limited functional or strength impairment in an upper extremity due to COVID-19 were enrolled in the study. A structured intervention consisted of 45 min therapy sessions, conducted four times per week over a six-week period, utilizing a hand exoskeleton. The research employed standardized health assessments, motion analysis, and semi-structured interviews for pre-intervention and follow-up evaluations. Paired sample t-tests were employed to statistically analyze the outcomes. Results: The outcomes showed a reduction in overall dependence levels across participants, positive changes in various quality of life-related measurements, and an average increase of 60.4 ± 25.7% and 28.7 ± 11.2% for passive and active flexion, respectively. Conclusions: Our data suggest that hand exoskeleton-based robotic systems hold promise to optimize the rehabilitation outcomes following severe COVID-19. Trial registration: ID NCT06137716 at ClinicalTrials.gov. PB MDPI YR 2024 FD 2024 LK https://uvadoc.uva.es/handle/10324/73268 UL https://uvadoc.uva.es/handle/10324/73268 LA spa NO Journal of Clinical Medicine, 2024, vol. 13, n. 6, p. 1543 DS UVaDOC RD 23-ene-2025