RT info:eu-repo/semantics/article
T1 Corollary discharge and anomalous self-experiences in schizophrenia and bipolar disorder: A specificity analysis
A1 Beño Ruiz De La Sierra, Rosa María
A1 Arjona Valladares, Antonio
A1 Hernández García, Marta
A1 Fernández Linsenbarth, Ines
A1 Díez Revuelta, Álvaro
A1 Roig Herrero, Alejandro
A1 Osorio Iriarte, María Emma
A1 Molina Rodríguez, Vicente
K1 Event-related potentials
K1 Auditory N1
K1 Suppression
K1 Speech
K1 Ipseity
K1 Psychosis
AB Objective: The Corollary Discharge (CD) mechanism inhibits self-generated speech sound perception, appearing disrupted in schizophrenia and potentially contributing to Anomalous Self-Experiences (ASEs). However, it remains unclear if this alteration and its correlation with ASEs extend to other psychotic disorders.Methods: Electroencephalography was used to study the N1 Event-Related Potential (ERP) as an index of CD-mediated suppression in the auditory cortex across thirty-five participants with schizophrenia, twenty-six with bipolar disorder, and thirty healthy controls. Auditory N1 was elicited by two conditions: real-time listening to self-pronounced vowels while speaking through connected microphone and earphones (listen/talk −or talk condition in previous literature-) and passive listening to the same previously recorded self-uttered vowels (listen/no talk −or listen condition-).Results: N1 ERP amplitude was lower in the listen/talk condition compared to listen/no talk across all groups. However, N1 suppression was significantly reduced in schizophrenia, with bipolar patients showing intermediate attenuation between both groups (i.e., non-significantly different from controls). Furthermore, N1 suppression inversely correlated with ASEs severity only in schizophrenia.Conclusions: Dysfunction of the CD mechanism may be a defining feature of schizophrenia, where it is connected to ASEs.Significance: These results corroborate previous findings linking auditory N1 ERP suppression with disrupted CD mechanism in schizophrenia, but not in bipolar disorder.
PB Elsevier
SN 1388-2457
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/73269
UL https://uvadoc.uva.es/handle/10324/73269
LA eng
NO Clinical Neurophysiology, octubre 2024, vol. 166, p. 87-95
NO Producción Científica
DS UVaDOC
RD 22-ene-2025