RT info:eu-repo/semantics/article
T1 Effect of a diabetes-specific formula in non-diabetic inpatients with stroke: a randomized controlled trial
A1 de luis roman, Daniel
AB BACKGROUND/OBJECTIVES: In patients with acute stroke, the presence of hyperglycaemia has been associated with highermorbidity and less neurological recovery. The aim of the study was to evaluate the impact of a diabetes specific enteral nutrition(EN) formula on glycaemia, comorbidities and mortality in patients admitted with a first episode of stroke who received completeEN.METHODS: This was a prospective randomised controlled trial. Patients with acute stroke did not have diagnosis of diabetesmellitus and required nasogastric tube feeding. This study has been registered with code NCT03422900. The patients wererandomised into two arms: an isocaloric isoprotein formula (control group (CG), 27 patients) vs a diabetes-specific formula (lowglycaemic index carbohydrates, fibre (80% soluble) and higher lipid content) (experimental group (EG), 25 patients). Pre-EN bloodglucose, hyperglycaemia during EN treatment, HbA1c, insulin use, oral route recovery, length of stay (LOS) and mortality at 30 dayswere collected. The complications of enteral nutrition during admission were collected as well.RESULTS: 52 patients were included, 50% females, with an age of 77.44(11.48) years; 34 (65.4%) had ischaemic stroke, with a Rankinscore of 0(0–2), and a National Institute of Health Stroke Scale (NIHSS) of 19 (15–22). In CG, there were more cases ofhyperglycaemia on the 5th day post-NE (13(65%) vs7(35%), p < 0.01). CG showed an OR of 7.58(1.49–39.16) (p = 0.02) for thedevelopment of hyperglycaemia. There were no differences in LOS between groups (12(8.5) days vs 14(23) days, p = 0.19) or in thedeath rate (10(37%) vs 10(40%), p = 0.8), although differences were found in terms of oral route recovery (EG: 11(44%) patients vsCG: 5(18.5%) patients, p = 0.04) (OR (EG): 5.53(1.25–24.47); p = 0.02).CONCLUSIONS: The use of a diabetes-specific enteral formula in non-diabetic patients admitted with acute stroke reduced the riskof developing hyperglycaemia and improved the rate of oral route recovery
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/73689
UL https://uvadoc.uva.es/handle/10324/73689
LA eng
NO Nutrition and Diabetes (2024) 14:34
DS UVaDOC
RD 23-ene-2025