RT info:eu-repo/semantics/article
T1 Role of rs2282679 in 25-hydroxyvitamin D levels and insulin resistance after a sleeve gastrectomy
A1 de Luis, Daniel
A1 Izaola, Olatz
A1 Primo, David
A1 López Gómez, Juan José
A1 Pacheco Sánchez, David
AB BACKGROUND & AIMS: Some studies have reported links between 25-hydroxyvitamin D levels and the presence of obesity andsome genetic variants. The aim of our design was to evaluate the effects of rs2282679 genetic variant of CG gene on 25-hydroxyvitamin D levels, weight loss and metabolic parameters after a robotic sleeve gastrectomy in premenopausal females withobesity.METHODS: 76 participants were enrolled. 25-hydroxyvitamin D levels, biochemical evaluation and anthropometric parameters wereregistered before surgery and after 3, 6 and 12 months follow up. Genotype of rs2282679 CG gene was evaluated.RESULTS: The improvements in anthropometric parameters, blood pressure and lipid profile were similar in both genotypes (TT vsTG+ GG). Basal insulin levels and HOMA-IR were greater in G allele carriers than non-carriers (Delta: 6.7 ± 1.2 mUI/L; p = 0.01) and(Delta: 1.3 ± 0.1 units; p =0.02). 25-hydroxyvitamin D levels were lower in G allele carriers than non-carriers (Delta: 8.1 ± 1.1 ng/dl;p =0.03). The levels of insulin and HOMA-IR remained greater in G allele carriers than non-carriers throughout all the visits. The levelsof 25-hydroxyvitamin D remained lower in G allele carriers than non-G allele. The average level of 25-hydroxyvitamin D at 12 monthsin non-G allele carriers were above 30 ng/dl (36.0 ± 3.1 ng/dl) and the level in G allele carriers were below (24.9 ± 4.9 ng/dl).CONCLUSIONS: rs 2282679 (GC) was related with low 25 hydroxyvitamin D levels and insulin resistance. In addition, the presence ofG allele produced a decrease in the improvement of 25-hydroxyvitamin D levels and insulin resistance after weight loss during12 months.
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/73693
UL https://uvadoc.uva.es/handle/10324/73693
LA spa
NO Nutrition and Diabetes, 2024, vol. 14, 12
DS UVaDOC
RD 31-ene-2025