RT info:eu-repo/semantics/article
T1 LYP regulates SLP76 and other adaptor proteins in T cells
A1 Ruiz-Martín, Virginia
A1 Marcos, Tamara
A1 de Pereda, José María
A1 Sánchez-Crespo, Mariano
A1 de la Fuente, Miguel Angel
A1 Bayón Prieto, Yolanda
A1 Alonso, Andrés
K1 Biomedicina
K1 FYB; LYP (lymphoid phosphatase); Protein tyrosine phosphatase (PTP); SKAP2; SLP76; T-cell; T-cell receptor (TCR).
K1 24 Ciencias de la Vida
AB BackgroundThe LYP tyrosine phosphatase presents a SNP (1858C > T) that increases the risk of developing autoimmune diseases such as type I diabetes and arthritis. It remains unclear how this SNP affects LYP function and promotes the development of these diseases. The scarce information about LYP substrates is in part responsible for the poor understanding of LYP function.ResultsIn this study, we identify in T lymphocytes several adaptor proteins as potential substrates targeted by LYP, including FYB, SLP-76, HS-1, Vav, SKAP1 and SKAP2. We also show that LYP co-localizes with SLP76 in microclusters, upon TCR engagement.ConclusionsThese data indicate that LYP may modulate T cell activation by dephosphorylating several adaptor proteins, such as FYB, SLP-76, HS-1, Vav, SKAP1 and SKAP2 upon TCR engagement.
PB BioMed Central (BMC)-Part of Springer Nature
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/73882
UL https://uvadoc.uva.es/handle/10324/73882
LA eng
NO Biological Research volume 57, Article number: 69 (2024)
NO Producción Científica
DS UVaDOC
RD 05-feb-2025