RT info:eu-repo/semantics/article
T1 Distributed rhythm generators underlie Caenorhabditis elegans forward locomotion
A1 Fouad, Anthony D
A1 Teng, Shelly
A1 Mark, Julian R
A1 Liu, Alice
A1 Alvarez-Illera, Pilar
A1 Ji, Hongfei
A1 Du, Angelica
A1 Bhirgoo, Priya D
A1 Cornblath, Eli
A1 Guan, Sihui Asuka
A1 Fang-Yen, Christopher
AB Coordinated rhythmic movements are ubiquitous in animal behavior. In many organisms, chains of neural oscillators underlie the generation of these rhythms. In C. elegans, locomotor wave generation has been poorly understood; in particular, it is unclear where in the circuit rhythms are generated, and whether there exists more than one such generator. We used optogenetic and ablation experiments to probe the nature of rhythm generation in the locomotor circuit. We found that multiple sections of forward locomotor circuitry are capable of independently generating rhythms. By perturbing different components of the motor circuit, we localize the source of secondary rhythms to cholinergic motor neurons in the midbody. Using rhythmic optogenetic perturbation, we demonstrate bidirectional entrainment of oscillations between different body regions. These results show that, as in many other vertebrates and invertebrates, the C. elegans motor circuit contains multiple oscillators that coordinate activity to generate behavior.
YR 2018
FD 2018
LK https://uvadoc.uva.es/handle/10324/73912
UL https://uvadoc.uva.es/handle/10324/73912
LA eng
NO Fouad AD, Teng S, Mark JR, Liu A, Alvarez-Illera P, Ji H, Du A, Bhirgoo PD, Cornblath E, Guan SA, Fang-Yen C. Distributed rhythm generators underlie Caenorhabditis elegans forward locomotion. Elife. 2018 Jan 23;7:e29913. doi: 10.7554/eLife.29913. PMID: 29360037; PMCID: PMC5780042.
DS UVaDOC
RD 05-feb-2025