RT info:eu-repo/semantics/article
T1 Relation between task-related activity modulation and cortical inhibitory function in schizophrenia and healthy controls: a TMS–EEG study
A1 Fernández Linsenbarth, Ines
A1 Mijancos Martínez, Gema
A1 Bachiller Matarranz, Alejandro
A1 Núñez Novo, Pablo
A1 Rodríguez González, Víctor
A1 Beño Ruiz De La Sierra, Rosa María
A1 Roig Herrero, Alejandro
A1 Arjona Valladares, Antonio
A1 Poza Crespo, Jesús
A1 Mañanas, Miguel Ángel
A1 Molina Rodríguez, Vicente
K1 Schizophrenia
K1 Cortical inhibition
K1 Spectral entropy
K1 Modulation
K1 Transcranial magnetic stimulation
K1 Dorsolateral prefrontal cortex
K1 3211 Psiquiatría
AB Schizophrenia has been associated with a reduced task-related modulation of cortical activity assessed through electroencephalography (EEG). However, to the best of our knowledge, no study so far has assessed the underpinnings of this decreased EEG modulation in schizophrenia. A possible substrate of these findings could be a decreased inhibitory function, a replicated finding in the field. In this pilot study, our aim was to explore the association between EEG modulation during a cognitive task and the inhibitory system function in vivo in a sample including healthy controls and patients with schizophrenia. We hypothesized that the replicated decreased task-related activity modulation during a cognitive task in schizophrenia would be related to a hypofunction of the inhibitory system. For this purpose, 27 healthy controls and 22 patients with schizophrenia (including 13 first episodes) performed a 3-condition auditory oddball task from which the spectral entropy modulation was calculated. In addition, cortical reactivity—as an index of the inhibitory function—was assessed by the administration of 75 monophasic transcranial magnetic stimulation single pulses over the left dorsolateral prefrontal cortex. Our results replicated the task-related cortical activity modulation deficit in schizophrenia patients. Moreover, schizophrenia patients showed higher cortical reactivity following transcranial magnetic stimulation single pulses over the left dorsolateral prefrontal cortex compared to healthy controls. Cortical reactivity was inversely associated with EEG modulation, supporting the idea that a hypofunction of the inhibitory system could hamper the task-related modulation of EEG activity.
PB Springer
SN 0940-1334
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/74239
UL https://uvadoc.uva.es/handle/10324/74239
LA eng
NO European Archives of Psychiatry and Clinical Neuroscience,2024, vol. 274, n. 4, p. 837-847
NO Producción Científica
DS UVaDOC
RD 22-ene-2025