RT info:eu-repo/semantics/article
T1 Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death
A1 Balgoma, David
A1 Kullenberg, Fredrik
A1 Calitz, Carlemi
A1 Kopsida, Maria
A1 Heindryckx, Femke
A1 Lennernäs, Hans
A1 Hedeland, Mikael
AB Metabolic and personalized interventions in cancer treatment require a better understanding of the relationship between the induction of cell death and metabolism. Consequently, we treated three primary liver cancer cell lines with two anthracyclins (doxorubicin and idarubin) and studied the changes in the lipidome. We found that both anthracyclins in the three cell lines increased the levels of polyunsaturated fatty acids (PUFAs) and alkylacylglycerophosphoethanolamines (etherPEs) with PUFAs. As PUFAs and alkylacylglycerophospholipids with PUFAs are fundamental in lipid peroxidation during ferroptotic cell death, our results suggest supplementation with PUFAs and/or etherPEs with PUFAs as a potential general adjuvant of anthracyclins. In contrast, neither the markers of de novo lipogenesis nor cholesterol lipids presented the same trend in all cell lines and treatments. In agreement with previous research, this suggests that modulation of the metabolism of cholesterol could be considered a specific adjuvant of anthracyclins depending on the type of tumor and the individual. Finally, in agreement with previous research, we found a relationship across the different cell types between: (i) the change in endoplasmic reticulum (ER) stress, and (ii) the imbalance between PUFAs and cholesterol and saturated lipids. In the light of previous research, this imbalance partially explains the sensitivity to anthracyclins of the different cells. In conclusion, our results suggest that the modulation of different lipid metabolic pathways may be considered for generalized and personalized metabochemotherapies.
PB MDPI
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/74601
UL https://uvadoc.uva.es/handle/10324/74601
LA spa
NO Cells. 2021 May 11;10(5):1163
NO Producción Científica
DS UVaDOC
RD 05-feb-2025