RT info:eu-repo/semantics/doctoralThesis
T1 Evaluación clínica y del rendimiento cognitivo y motor en niños en seguimiento en salud mental y antecedentes familiares de trastornos del espectro de la esquizofrenia
A1 Parrilla Escobar, María Avelina
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Esquizofrenia
K1 Schizophrenia
K1 Esquizofrenia
K1 Neurodevelopment
K1 Neurodesarrollo
K1 Motor functioning
K1 Rendimiento motor
K1 Cognition
K1 Cognición
K1 32 Ciencias Médicas
AB INTRODUCTIONEthiopatogenic models of schizophrenia take in consideration neurodevelopmental theories. Premorbid motor and cognitive problems, poor social adjustment and internalizing and externalizing psychopathology have been described in patients with schizophrenia. It has been postulated that combination of several neurodevelopmental markers and “Thought Problems” CBCL subscale may help identify those ah higher risk. OBJECTIVEIn a child and adolescent outpatient psychiatric clinic, we expect to define a group with more schizophrenia spectrum disorders (SSD) theoretical risk, based on neurodevelopmental premorbid characteristics, including current psychopathology, cognitive and motor performance and family history of the disease. We expect that a group of patients with family history of SSD and/or clinical scores on Child Behavior Checklist (CBCL) Thought Problems subscale present with more internalizing, social and attention problems and also lower performance on general cognition, social cognition, executive function and motor function. METHODSSeventy-five children (aged 7 to 16; mean 12 y/o; 53% males) were recruited (45 reported family history). They completed the Wechsler Intelligence Scale for Children (WISC-V), Movement Assessment Battery for Children (MABC-2), social cognition from the Developmental NEuroPSYchological Assessment (NEPSY-II) and Conners Continuous Performance Test (CPT-3). Parents completed the Child Behavior Checklist (CBCL) and Behavior Rating Inventory of Executive Function (BRIEF-2).RESULTSA neurodevelopmental disorder was the primary diagnosis in 65% (mainly ADHD). Motor performance and emotion recognition were below expected by age, and IQ and attention was average. Males performed worse in manual dexterity and presented more neurodevelopmental disorders. No relevant differences in relation to family history were found (except more attention problems in those with no family history of SSD). The main finding is that patients with clinical scores on Thought Problems subscale had symptoms in Internalizing subscales (Anxious/Depressed, Withdrawal/Depressed, somatic problems) and Attention and social problems on CBCL, and more externalizing symptoms, although below the clinical range. This group more often presented a secondary diagnosis, lived in urban area, had Executive Function problems and performed worse in Emotion Recognition (and more often made “angry” errors). No differences were found on sustained attention, general cognition, motor performance or theory of mind. CONCLUSIONSWe consider that this group of children and adolescents with elevated scores on Thought Problems CBCL subscale deserves more attention in clinical practice because they present with several risk markers. It would be recommended to implement therapeutical and preventive strategies adressing executive function, motor dexterity and social cognition. Longitudinal follow-up will inform about the relationship between precursors, other environmental factors and the development of SSD or other forms of psychopathology.
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/74681
UL https://uvadoc.uva.es/handle/10324/74681
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 26-feb-2025