RT info:eu-repo/semantics/article
T1 Advanced technologies for marine drugs large scale supply
A1 Martínez García, María del Henar
A1 Santos García, María Mercedes
A1 Pedraza, Lucía
A1 Testera Gorgojo, Ana María
K1 total synthesis
K1 aquaculture
K1 chemoenzymatic synthesis
K1 fermentation
K1 ex vivo biosynthesis
K1 production strategies
K1 cell factory
K1 2306 Química Orgánica
AB Marine organisms represent a source of unique chemical entities with valuable biomedical potentialities, broad diversity and complexity. It is essential to ensure a reliable and sustainable supply of marine natural products (MNPs) for their translation into commercial drugs and other valuable products. From a structural point of view and with few exceptions, MNPs of pharmaceutical importance derive from the so-called secondary metabolism of marine organisms. When production strategies relied on marine macroorganism, harvesting or culturing coupled with extraction procedures re-main sometimes the only alternative to produce these compounds at industrial scale. Their supply can be often implemented with laboratory scale cultures for bacterial, fungal or microalgal sources. However, a diverse approach, combining traditional methods with a modern synthetic biology and biosynthesis strategies, must be considered for invertebrate MNPs, as they are usually naturally accumulated in only very small quantities. This review offers a comprehensive examination of various production strategies for MNPs, addressing the challenges related to supply, synthesis, and scalability. It also underscores recent biotechnological advancements that are likely to transform the current industrial-scale manufacturing methods for pharmaceuticals derived from marine sources.
PB MDPI
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/74821
UL https://uvadoc.uva.es/handle/10324/74821
LA eng
NO [Preprint]
NO Producción Científica
DS UVaDOC
RD 23-feb-2025