RT info:eu-repo/semantics/bookPart
T1 Designing elastin-like recombinamers for rherapeutic and regenerative purposes
A1 Rodríguez Cabello, José Carlos
A1 Escalera Anzola, Sara
A1 Juanes Gusano, Diana
A1 Santos García, María Mercedes
A1 Girotti ., Alessandra
K1 23 Química
K1 32 Ciencias Médicas
AB Elastin-like recombinamers (ELRs) are proteinaceous biopolymers obtained by recombinant technology and which sequence is inspired by natural elastin. Genetic engineering allows total control over amino acid sequence and design of ELR structures in a versatile way that can include bioactive, structural, or functional domains. ELRs can be used as precursors of bioactive and biocompatible hydrogels generated by either physical or chemical interchain cross-linking. This chapter describes ELR-based hydrogels, their principal features, and applications in biomedical field. We focus on the use of these hydrogels as advanced scaffolds mimicking extracellular matrix in tissue engineering, reviewing the most interesting and recent examples of musculoskeletal, cardiovascular, skin, and neural tissue regeneration. Advanced drug delivery devices based on ELRs hydrogels are also reviewed concerning their application in disease therapies, such as type 2 diabetes, ischemia, or glaucoma, and focusing mainly on cancer therapy.
PB Wiley
SN 9783527347162
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/74851
UL https://uvadoc.uva.es/handle/10324/74851
LA eng
NO Pires, Ricardo A., Pashkuleva, Iva, Reis, Rui L. (eds.). Multifunctional hydrogels for biomedical applications. Weinheim: Wiley-VCH, 2022, p. 37-62
NO Producción Científica
DS UVaDOC
RD 19-abr-2025