RT info:eu-repo/semantics/article
T1 Effect of hematopoietic stem cell transplantation on meibomian gland structure
A1 Novo Díez, Andrea
A1 Horstmann, Jens
A1 Fernández Martínez, Itziar
A1 Calonge, Margarita
A1 González García, María Jesús
A1 Steven, Philipp
AB Purpose: To assess morphological changes in the meibomian glands (MGs) pre- and post-hematopoietic stem cell transplantation (HSCT).Methods: Participants yet to undergo HSCT were included in a pre-HSCT group. Meibography images of both lids were graded using Pult’s meiboscale and analyzed using a semi-automatic software program. Meibography variables in the pre-HSCT group were compared with those in a control group of healthy participants. The follow-up group, a subset of the pre-HSCT group, comprised participants followed up for at least 6 months post-HSCT. Ocular Surface Disease Index (OSDI), tear break-up time, corneal fluorescein staining, and Schirmer test were performed. The differences in meibography variables and ocular surface tests pre- and post-HSCT were analyzed.Results: Pre-HSCT and control groups comprised 181 and 24 participants, respectively. The pre-HSCT group had a higher meiboscale in the lower lid (2  vs. 1, p = 0.011) than controls. The follow-up group comprised 20 patients followed up for 12.75 months post-HSCT. After HSCT, the meiboscale of the upper lid was higher (2  vs. 1, p = 0.011), the MG area was lower in both lids (upper lid = 16.14%  vs. 21.49%, p = 0.001; lower lid = 11.92%  vs. 17.59%, p = 0.011), and the OSDI increased (15.2  vs. 26.85, p = 0.018) in the second visit compared to the first visit.Conclusions: Alterations in meibography were observed in patients pre- and post-HSCT. This may be attributed to the effect of treatments administered pre-HSCT, although an additive effect of conditioning regimen in the long-term cannot be discarded.
PB Elsevier
SN 1542-0124
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/74853
UL https://uvadoc.uva.es/handle/10324/74853
LA eng
NO The Ocular Surface, enero 2025, vol. 36, p. 173-180
NO Producción Científica
DS UVaDOC
RD 14-abr-2025