RT info:eu-repo/semantics/article
T1 Effects of gestational intermittent hypoxia on the respiratory system: A tale of the placenta, fetus, and developing offspring
A1 Valverde Pérez, Esther
A1 Olea Fraile, Elena
A1 Rocher Martín, María Asunción
A1 Philip I., Aaronson
A1 Prieto Lloret, Jesús
K1 fetus
K1 gestational intermittent hypoxia
K1 obstructive sleep apnea
K1 offspring
K1 oxidative stress
K1 placenta
K1 pregnancy
K1 respiratory system
K1 32 Ciencias Médicas
AB Obstructive sleep apnea (OSA) is a common sleep disorder that is associated with a wide variety of health conditions, including cardiovascular, cerebrovascular, metabolic, neoplastic, and neurocognitive manifestations. OSA, as a chronic condition, is mainly characterised by repeated upper airway obstructions during sleep that cause episodes of intermittent hypoxia (IH), resulting in tissue hypoxia–reoxygenation cycles. Decreased arterial oxygen pressure (PaO2) and haemoglobin saturation (SatO2) stimulate reflex responses to overcome the obstruction. The prevalence of OSA is significant worldwide, and an underrated problem when focussing on women during pregnancy. The physiological changes associated with pregnancy, especially during its latest stages, are related to a higher prevalence of OSA events in pregnant mothers, and associated with an increased risk of hypertension, pre-eclampsia and diabetes, among other deleterious consequences. Furthermore, OSA during pregnancy can interfere with normal fetal development and is associated with growth retardation, preterm birth, or low birth weight. Carotid body overstimulation and hypoxia–reoxygenation episodes contribute to cardiovascular disease and oxidative stress, which can harm both mother and fetus and have long-lasting effects that can reach into adulthood. Because IH is the hallmark of OSA, this review examines the literature available about the impact of gestational intermittent hypoxia (GIH) on the respiratory system at maternal, fetal, and offspring levels. Offering the latest scientific data about OSA during pregnancy, we may help to tackle this condition with lifestyle changes and therapeutic approaches, that could influence the mothers, but also impact adult health problems, mostly unknown, inherited from these hypoxic episodes in the uterus.
PB Wiley
SN 0962-1105
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/75155
UL https://uvadoc.uva.es/handle/10324/75155
LA eng
NO Journal of Sleep Research, [Early View]
NO Producción Científica
DS UVaDOC
RD 23-jun-2025