RT info:eu-repo/semantics/article
T1 Quality of life, diabetes-related stress and treatment satisfaction are correlated with glycemia risk index (GRI), time in range and hypoglycemia/hyperglycemia components in type 1 diabetes
A1 Díaz Soto, Gonzalo
A1 Pérez López, Paloma
A1 Fernández Velasco, Pablo
A1 Bahillo Curieses, María del Pilar
A1 Nieto de la Marca, María de la O
A1 Jimenez, Rebeca
A1 Luis Román, Daniel Antonio de
K1 GRI
K1 Quality of life
K1 Diabetes related stress
K1 TIR
K1 32 Ciencias Médicas
AB Introduction To evaluate the relationship between the GRI -component of hypoglycemia (CHypo) and hyperglycemia(CHyper)- with diabetes quality of life (DQoL), diabetes-related stress (DDS), perception of hypoglycemia (Clarke Test),visual analogic scale (VAS) and diabetes-knowledge (DKQ2) in T1D.Methods Cross-sectional study in 92 patients with T1D under intensive insulin treatment (21.7% CSII) and flash glucosemonitoring (isCGM). Clinical, metabolic and glycometric parameters and quality of life/satisfaction questionnaires wereanalyzed.Results 92 patients (54.3% male, BMI 25.4 ± 4.5 kg/m 2 , HbA1c 7.5 ± 1.0%, TIR 53.9 ± 15.9%) with mean age36.1 ± 12.6years and 17.8 ± 11.3 T1D duration. The mean GRI was 60.6 ± 22.2 with a CHypo and CHyper of 5.9 ± 4.8and 27.3 ± 14.4, respectively. 19.1% presented a pathological Clarke’s test. Patients with TIR > 70% andGRI < 40 showed better VAS (8.8 ± 1.3 vs 9.3 ± 0.9, p < 0.05) and DDS (46.4 ± 22.1 vs 36.7 ± 16.6, p < 0.05) scores,showing no differences between groups. CHyper > 15 and Chypo > 3.4 were related to worse levels of DQoL(91.1 ± 23.9 vs 76.6 ± 18.6 and 94.6 ± 24.8 vs 79.8 ± 20.1, p < 0.01), DDS(49.8 ± 22.4 vs 35.7 ± 16.5 and 49.8 ± 22.4vs 35.7 ± 16.5, p < 0.01),and DKQ2 (24.4 ± 4.3 vs 26.8 ± 5.2 and 24.1 ± 4.8 vs 26.0 ± 4.6, p < 0.05), respectively.Worse metabolic control defined by GRI correlated with worse scores in VAS (r = −0.209, p < 0.05), DQoL(r = 0.205, p < 0.05), and DDS (r = 0.205, p < 0.05). No difference was observed in knowledge´s scale. CHypercorrelated with worse scores in VAS (r = −0.231, p < 0.05), DQoL (r = 0.422, p < 0.01), and DDS (r = 0.341,p < 0.01) and lower degree of knowledge DKQ2 (r = −0.231, p < 0.05). When analyzing DQoL as a dependentvariable in a multiple lineal regression, only age (β = 0.747; p < 0.001) and CHyper (β = 0.717; p < 0.001) maintainedstatistical significance.Conclusions Higher GRI was related to worse quality of life, diabetes-related stress and satisfaction with treatment,analogous to the TIR results.CHyper an Chypo were related to a greater decline in quality of life, diabetes-related stress,and lower satisfaction with treatment.However, in a multiple linear regression, only CHyper maintained statisticalsignificance.
PB Springer
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/75180
UL https://uvadoc.uva.es/handle/10324/75180
LA eng
NO Endocrine, 2024, vol. 86, n. 1, p. 186-193
NO Producción Científica
DS UVaDOC
RD 03-mar-2025