RT info:eu-repo/semantics/article
T1 Utility of time in tight range (TITR) in evaluating metabolic control in pediatric and adult patients with type 1 diabetes in treatment with advanced hybrid closed-loop systems
A1 Bahillo Curieses, María del Pilar
A1 Fernández Velasco, Pablo
A1 Pérez López, Paloma
A1 Vidueira Martínez, Ana María
A1 Nieto de la Marca, María de la O
A1 Díaz Soto, Gonzalo
K1 Type 1 diabetes
K1 Time in range
K1 Time in tight range
K1 Advanced hybrid closed loop
K1 Glucose variability
K1 32 Ciencias Médicas
AB Purpose To analyze the time in tight range (TITR), and its relationship with other glucometric parameters in patients withtype 1 diabetes (T1D) treated with advanced hybrid closed-loop (AHCL) systems.Methods A prospective observational study was conducted on pediatric and adult patients with T1D undergoing treatmentwith AHCL systems for at least 3 months. Clinical variables and glucometric parameters before and after AHCL initiationwere collected.Results A total of 117 patients were evaluated. Comparison of metabolic control after AHCL initiation showed significantimprovements in HbA1c (6.9 ± 0.9 vs. 6.6 ± 0.5%, p < 0.001), time in range (TIR) (68.2 ± 11.5 vs. 82.5 ± 6.9%, p < 0.001),TITR (43.7 ± 10.8 vs. 57.3 ± 9.7%, p < 0.001), glucose management indicator (GMI) (6.9 ± 0.4 vs. 6.6 ± 0.3%, p < 0.001),time below range (TBR) 70–54 mg/dl (4.3 ± 4.5 vs. 2.0 ± 1.4%, p < 0.001), and time above range (TAR) > 180 mg/dl(36.0 ± 7.6 vs. 15.1 ± 6.4%, p < 0.001). Coefficient of variation (CV) also improved (36.3 ± 5.7 vs. 30.6 ± 3.7, p < 0.001),while time between 140–180 mg/dl remained unchanged. In total, 76.3% achieved TITR > 50% (100% pediatric). Corre-lation analysis between TITR and TIR and GRI showed a strong positive correlation, modified by glycemic variability.Conclusions AHCL systems achieve significant improvements in metabolic control (TIR > 70% in 93.9% patients). Theincrease in TIR was not related to an increase in TIR 140–180 mg/dl. Despite being closely related to TIR, TITR allows for amore adequate discrimination of the achieved control level, especially in a population with good initial metabolic control.The correlation between TIR and TITR is directly influenced by the degree of glycemic variability.
PB Springer
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/75197
UL https://uvadoc.uva.es/handle/10324/75197
LA eng
NO Endocrine, 2024, vol. 86, n. 2, p. 539-545
NO Producción Científica
DS UVaDOC
RD 03-mar-2025