RT info:eu-repo/semantics/article
T1 Bacterial toxicity of Acetaminophen and Edaravone, and their binary mixtures: experimental and predicted values using traditional and novel Van Laar-based models
A1 Álvarez Escalante, Iván Alejandro
A1 Martínez Páramo, Sonia
A1 Irusta Mata, Rubén
K1 Microtox
K1 Pharmaceuticals
K1 Binary mixtures
K1 Concentration Addition
K1 Independent Action
K1 Van Laar-based model
AB In recent years, the presence of Pharmaceutical Active Compounds (PhACs) in ecosystems has become a seriousenvironmental problem due to their capacity to induce harmful effects at extremely low concentrations in both humans andwildlife. Water treatment plants have not been designed to remove these types of compounds efficiently. Thus, the detectionof these pollutants is essential to evaluate their negative impacts and is one of the emerging issues in environmentalchemistry. The main objective of this study is to determine the bacterial toxicity of two PhACs (both individually and as amixture) through the quantification of bioluminescence inhibition in the marine bacteria Aliivibrio fischeri, a commonly usedmethod in short-term toxicity tests. In this work, Acetaminophen and Edaravone, two drugs approved by the Food and DrugAdministration, have been studied. The acute toxicity of these PhACs has been tested at two exposure times (5 and 15 min)and different concentrations, by estimation of the median effective concentration (EC 50) for each individual compound or incombination at different concentrations. Moreover, the EC 50 of the binary mixtures Acetaminophen/Edaravone have beenforecast using two traditional predictive models, Concentration Addition and Independent Action. The results show thattoxicity decreases with exposure time and depends on the concentration tested. Furthermore, a novel semi-empirical VanLaar-based model has been proposed and validated with the experimental data from this study and literature data, obtainingsatisfactory estimations of the EC 50 for binary mixtures
PB Springer
SN 0963-9292
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/75205
UL https://uvadoc.uva.es/handle/10324/75205
LA eng
NO Ecotoxicology,2024,vol.33, n.7, p.722-736
NO Producción Científica
DS UVaDOC
RD 29-jun-2025