RT info:eu-repo/semantics/bookPart
T1 Cell therapy using extraocular cells: mesenchymal stem cells
A1 Nieto Miguel, Teresa
A1 Galindo de la Rosa, Sara
A1 López Paniagua, Marina
A1 Pérez Soto, María Inmaculada
A1 Herreras Cantalapiedra, José María
A1 Calonge, Margarita
K1 Cornea
K1 Ocular surface
K1 Cell therapy
K1 Mesenchymal stem cells
K1 Regeneration
K1 2410 Biología Humana
K1 2407 Biología Celular
K1 3201.09 Oftalmología
AB Extraocular mesenchymal stem cells (MSCs) represent an available, non-immunogenic source of stem cells that has proved to possess a potential therapeutic value in corneal epithelium regeneration based on results obtained in both preclinical and clinical studies. All published studies have revealed promising results in animal models and have shown significant corneal regeneration, improved corneal transparency and a rapid healing process associated with the restoration of vision. However, the studies performed to unravel the mechanisms underlying the beneficial effects of MSCs on the damaged ocular surface have shown that multiple mechanisms might contribute simultaneously to their therapeutic action. Although it remains uncertain if MSCs can transdifferentiate into corneal epithelial cells, these cells have shown a capacity of secreting trophic and growth factors capable of stimulating resident stem cells and reducing tissue injury, an ability to exert anti-inflammatory and immunomodulatory effects, and a capability to migrate into injured tissues. This book chapter is specifically focused on the preclinical and clinical advancements on the use of extraocular MSCs for corneal epithelium regeneration.
PB Springer Nature
SN 978-3-030-01304-2
YR 2019
FD 2019
LK https://uvadoc.uva.es/handle/10324/75613
UL https://uvadoc.uva.es/handle/10324/75613
LA eng
NO Nieto-Miguel, T., Galindo, S., López-Paniagua, M., Pérez, I., Herreras, J.M., Calonge, M. Cell Therapy Using Extraocular Mesenchymal Stem Cells. In: Alió, J., Alió del Barrio, J., Arnalich-Montiel, F. (eds) Corneal Regeneration . Essentials in Ophthalmology. Springer, Cham. Nieto-Miguel, T., Galindo, S., López-Paniagua, M., Pérez, I., Herreras, J.M., Calonge, M. (2019). Cell Therapy Using Extraocular Mesenchymal Stem Cells. In: Alió, J., Alió del Barrio, J., Arnalich-Montiel, F. (eds) Corneal Regeneration . Essentials in Ophthalmology. Springer, Cham. 2019, p. 231-262 .
NO Producción Científica
DS UVaDOC
RD 01-jun-2025