RT info:eu-repo/semantics/doctoralThesis T1 Complicaciones a largo plazo de la colangiopancreatografía retrógrada endoscópica con esfinterotomía en el tratamiento de patología biliar benigna A1 Ibañez García, Mercedes A2 Universidad de Valladolid. Escuela de Doctorado K1 Sistema biliar- pancreático K1 Cholangiopancreatography K1 Colangiopancreatografía K1 Cholangitis K1 Colangitis K1 Choledocolithiasis K1 Coledocolitiasis K1 Pancreatitis K1 Pancreatitis K1 32 Ciencias Médicas AB INTRODUCTION AND AIMS: Endoscopic retrograde cholangiopancreatography (ERCP) is the preferred technique for treating pathologies of the bile duct. It has been suggested that this procedure, combined with sphincterotomy, may influence the subsequent development of long-term complications.The main objective of this study was to determine the long-term complications of biliopancreatic disease after ERCP and their potential association with the development of biliopancreatic neoplasms.MATERIALS AND METHODS: This retrospective cohort study included 576 patients who underwent ERCP (referred to as index ERCP) with sphincterotomy for benign biliary disease, with a minimum follow-up period of more than 2 years.RESULTS: The incidence of long-term benign and neoplastic pathologies after ERCP was analyzed. The most common findings were recurrence of choledocholithiasis in 70 patients (12.1%), cholangitis "sine materia" in 27 patients (4.7%), and acute pancreatitis in 8 patients (1.4%). Eight patients (1.4%) developed hepatobiliopancreatic neoplasms, including 4 cases of pancreatic neoplasms (0.7%), 1 cholangiocarcinoma (0.2%), 1 ampulloma (0.2%), and 2 intrahepatic neoplasms (0.3%). Multivariate analysis revealed that age over 50 years, previous biliary surgery, diversion of the bile duct (BD) to the digestive tract, dilation of the BD, stent placement, biopsy, and cholecystectomy were factors associated with an increased risk of long-term benign complications.CONCLUSIONS: ERCP with sphincterotomy is associated with an increased long-term risk of subsequent benign biliopancreatic disease. However, our data does not allow us to establish a direct relationship with the development of biliopancreatic neoplasms.KEYWORDS: Endoscopic retrograde cholangiopancreatography, complications, choledocholithiasis, cholangitis, pancreatitis. YR 2025 FD 2025 LK https://uvadoc.uva.es/handle/10324/75846 UL https://uvadoc.uva.es/handle/10324/75846 LA spa NO Escuela de Doctorado DS UVaDOC RD 02-jul-2025