RT info:eu-repo/semantics/doctoralThesis
T1 Dolor ocular neuropático en la enfermedad de ojo seco post-cirugía refractiva
A1 Vázquez Hernández, Amanda
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Ojo seco
K1 Dry eye disease
K1 Enfermedad de ojo seco
K1 Chronic ocular pain
K1 Dolor ocular crónico
K1 Neuropathic pain
K1 Dolor neuropático
K1 Refractive surgery
K1 Cirugía refractiva
K1 3201.09 Oftalmología
AB Dry eye disease (DED) is a common complication of refractive surgery (RS), which usually resolves within 6 to 12 months postoperatively but can persist chronically and be accompanied by pain.More and more patients are undergoing RS, especially surface techniques that reshape the corneal stroma to eliminate the need for glasses or contact lenses (CL). These procedures involve manipulating the corneal nerve plexus. The cornea, part of the Lacrimal Functional Unit (LFU), is responsible for maintaining the homeostatic balance of the ocular surface.When DED becomes chronic, it can be accompanied by pain, which can be nociceptive (caused by damage to the eye or surrounding tissues and subsiding when the tissue damage is repaired) or neuropathic (with no visible agent causing it, and if there was, it has already disappeared, but the pathway conducting sensitivity to the nerve centers is damaged). This latter type of pain is harder to diagnose and more resistant to standard treatments for ocular inflammation and nociceptive pain.It is crucial to study the possible risk factors involved in its onset and to take an early approach to try to avoid the sensitization of nociceptors, which can lead to the chronification and centralization of pain.This doctoral thesis aimed to exhaustively phenotype a sample of patients who, after undergoing RS, had developed DED and/or chronic post-RS ocular pain. Additionally, it studied the specific characteristics of a subset of these patients who, having undergone the same RS technique, developed not only DED but also chronic neuropathic ocular pain (NOP), and compared them with a similar sample of subjects who, having undergone the same surgical technique, remained asymptomatic, in search of data that could help identify objective methods for assessing NOP.
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/75848
UL https://uvadoc.uva.es/handle/10324/75848
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 04-ago-2025