RT info:eu-repo/semantics/doctoralThesis
T1 Contact lens discomfort characterization
A1 Valencia Nieto, Laura
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Lente de contacto
K1 Contact lens
K1 Lente de contacto
K1 Ocular surface
K1 Superficie ocular
K1 Questionnaire
K1 Cuestionario
K1 Discomfort
K1 Incomodidad
K1 3201.09 Oftalmología
AB This Doctoral Thesis consists of three different studies: a retrospective study performed at the Institute of Applied Ophthalmobiology (IOBA, Valladolid, Spain), a prospective cross-sectional study performed at IOBA, and a prospective cross-sectional study performed at the University of New South Wales (UNSW, Sydney, Australia) in accordance with the requirements to obtain the “International mention” of the Doctorate Degree. The retrospective study was conducted to describe how contact lens (CL) prescription patterns have changed over a long-term period in the same sample of CL wearers, and to determine the predisposing factors responsible for the observed changes in CL fittings. Within the prospective cross-sectional study conducted at IOBA, different research works were carried out. The repeatability of the CA-800 Corneal Analyzer (Topcon Healthcare, Oakland, NJ) when measuring non-invasive tear break-up time and tear meniscus height was evaluated in CL wearers. The eyelid health status was compared between the asymptomatic and symptomatic CL wearers, and the relationship between the eyelid alterations and the presence of CL discomfort (CLD) was evaluated. The subjective and objective differences among the steps of the CLD progression classification established by the Tear Film and Ocular Surface Society using questionnaires and clinical signs were evaluated, and a simplified classification was proposed. Finally, a model was developed to identify the most powerful parameters involved in the development of CLD, considering a broad range of clinical signs and symptom questionnaires, as well as intrinsic individual parameters and CL wearing characteristics.The prospective cross-sectional study performed during the 3-month stay at the School of Optometry and Vision Science of the UNSW was conducted to evaluate the association between corneal immune cell dynamics, CL comfort, and the concentration of tear inflammatory markers.
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/75849
UL https://uvadoc.uva.es/handle/10324/75849
LA eng
NO Escuela de Doctorado
DS UVaDOC
RD 02-jun-2025