RT info:eu-repo/semantics/doctoralThesis
T1 Laser-ablation rotational spectroscopy: structural and chiral studies of amino acids and amino sugars
A1 Aguado Vesperinas, Raúl
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Biomoléculas
K1 Rotational spectroscopy
K1 Espectroscopía de rotación
K1 Physical Chemistry
K1 Química Fisica
K1 Biomolecules
K1 Biomoléculas
K1 Chirality
K1 Quiralidad
K1 2302.26 Bioquímica Física
AB Rotational spectroscopy is a spectroscopic technique that exploits the interaction between gas-phase molecules and microwave radiation; can be applied to the study of any molecular system with a non-zero dipolar momentum and allows to obtain very accurate structural parameters of the studied system. Since its foundation, the GEM group has been devoted to the use of rotational spectroscopic techniques for the study of a wide variety of molecules; moreover, the work of the group for implementing the laser-ablation as vaporization system, has been proved as an unparalleled technique for investigating the structure of molecules with a high level of detail, even for those solid.  In this context, the present Thesis aims to still improving the experimental systems of GEM group and push them to their limits to obtain high-quality data about different relevant biomolecules, such as amino acids, cancer-associated amino sugars, and neurotransmitter mimetics. These results are going to be analyzed in their biological context, helping to obtain a molecular understanding on some key biological processes. In addition, another objective of the present Work is to face the actual limitation of the rotational spectroscopy when studying the chirality of a given sample; this technique is not capable of distinguishing between enantiomers of a chiral molecule. However, in the latest years the formation of molecular pairs of chiral molecules has been exploited for the characterization of the chirality by means of rotational spectroscopy but has been only possible for gaseous or volatile samples. Thus, some experimental and procedural improvements are going to be made looking forward forming molecular pairs of solid biomolecules for the first time. This will allow to resolve the 3-dimensional structure and the chirality of a sample at the same time with the sensitivity and precision inherent to rotational spectroscopy.
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/75854
UL https://uvadoc.uva.es/handle/10324/75854
LA eng
NO Escuela de Doctorado
DS UVaDOC
RD 02-jun-2025