RT info:eu-repo/semantics/article
T1 Organocatalytic kinetic resolution of 1,5-dicarbonyl compounds through a retro-Michael reaction
A1 Guevara Pulido, James Oswaldo
A1 González Pérez, Fernando
A1 Andrés García, José María
A1 Pedrosa Sáez, Rafael
K1 1,5 dicarbonyl
K1 Equilibrium
K1 Kinetic resolution
K1 Organocatalysis
K1 Retro-Michael
AB The pharmaceutical chemical industry has long used kinetic resolution to obtain high-value compounds. Organocatalysis has recently been added to this strategy, allowing for the resolution of racemic mixtures with low catalyst loadings and mild reaction conditions. This research focuses on the kinetic resolution of 1,5-dicarbonyl compounds using a retro-Michael reaction, co-catalyzed at room temperature with 20 mol % of the Jørgensen–Hayashi catalyst and PNBA. The study highlights the importance of conducting the kinetic resolution at a concentration of approximately ten millimolar (mM) to prevent the Michael retro-Michael equilibrium from affecting the process.
PB Beilstein Institut
SN 1860-5397
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/75888
UL https://uvadoc.uva.es/handle/10324/75888
LA spa
NO Guevara-Pulido, J.; González-Pérez, F.; Andrés, J. M.; Pedrosa, R. Beilstein J. Org. Chem. 2025, 21, 473–482. doi:10.3762/bjoc.21.34
DS UVaDOC
RD 03-jul-2025