RT info:eu-repo/semantics/doctoralThesis
T1 Evidencia de la contribución de la microbiota intestinal en enfermedades inflamatorias crónicas: interacciones con el exceso de peso y procesos fisiopatológicos asociados.
A1 Chero Sandoval, Lourdes Mariell
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Microbiota intestinal
K1 Gut microbiota
K1 Microbiota intestinal
K1 Bifidobacterium
K1 Inflammation
K1 Inflamación
K1 Systemic lupus erythematosus
K1 Lupus eritematoso sistémico
K1 32 Ciencias Médicas
AB Inflammation is a complex pathophysiological process that is essential as a defensive response to trauma and infection. When this inflammation persists over time it acquires a pathological character, causing damage to tissues and organs. This chronic inflammatory state is characteristic of autoimmune diseases such as systemic lupus erythematosus (SLE), post-viral multifactorial syndromes such as persistent COVID (PC) and metabolic diseases related to excess weight such as obesity-associated metabolic inflammation (MI), even influencing cardiovascular risk. In this context, one of the key factors associated with chronic inflammation is excess adipose tissue, often reflected by an elevated body mass index (BMI). Adipose tissue stimulates the release of pro-inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP), which are indicators of inflammatory status. Chronic inflammation not only has a systemic impact but is also related to an imbalance in the composition and functionality of the gut microbiota. This alteration leads to changes in the gut ecosystem, favoring the release of toxins and pro-inflammatory metabolites by certain bacteria, which perpetuates immune exacerbation and inflammatory state. Therefore, the axis of interaction between excess body weight, clinical inflammatory markers and gut microbiota represents a fundamental area of study to understand the mechanisms underlying these conditions. For this reason, an integrated approach that considers these three factors in clinical practice would advance the development of more effective strategies for the prevention, treatment and management of chronic inflammatory diseases.
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/76138
UL https://uvadoc.uva.es/handle/10324/76138
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 30-jun-2025