RT info:eu-repo/semantics/article
T1 Role of rs490683 variant in the promoter region of the ghrelin receptor gene on body weight and metabolic syndrome after a partial meal replacement hypocaloric diet
A1 Luis Román, Daniel Antonio de
A1 Izaola Jauregui, Olatz
A1 Primo, David
A1 Rico, Daniel
A1 López Gómez, Juan José
K1 rs490683
K1 Partial meal replacement diet
K1 GHSR gene
K1 Body weight
K1 32 Ciencias Médicas
AB Background and aims: Few studies have evaluated the effect of rs490683 on weight loss. The objective of ourstudy was to evaluate the role of this variant of GHSR gene on body weight loss and cardiovascular risk factorssecondary to a partial meal replacement (pMR) hypocaloric diet.Methods: 96 individuals with a body mass index (BMI > 35 kg/m2) were enrolled. Participants consumed anormocaloric, hyperproteic formula twice daily (12-w). Measurements were taken for body weight, BMI, fatmass, waist circumference, blood pressure, lipid profile, fasting insulin levels and HOMA-IR.Results: The genotype was 70 patients (72.9 %) CC genotype, 19 patients(19.8 %) CG genotype, and 7 patients(7.3 %) GG genotype. The intake of calories, grams of carbohydrates, fats and proteins was higher at 12w inpatients carrying the G allele. BMI ( 3.5 ± 0.4 kg/m2 vs  1.0 ± 0.2 kg/m2 (p = 0.01)), body weight ( 8.5 ±1.0 kg vs  2.6 ± 1.1 kg (p = 0.01)), fat mass ( 7.7 ± 0.3 kg vs  2.6 ± 0.2 kg (p = 0.01)), waist circumference( 7.2 ± 0.3 cm vs  2.9 ± 0.1 cm (p = 0.01)), glucose levels ( 12.1 ± 1.4 mg/dl vs  3.1 ± 1.8 mg/dl, p = 0.01),insulin ( 10.8 ± 1.2 UI/L vs  3.9 ± 1.1 UI/L, p = 0.01), HOMA-IR ( 2.1 ± 1.0 units vs  0.58 ± 0.2 units, p =0.01), CRP ( 1.2 ± 0.1 mg/dl vs  0.7 ± 0.2 mg/dl, p = 0.01), triglycerides ( 22.1 ± 4.1 mg/dl vs  5.1 ± 3.2mg/dl, p = 0.01), total-cholesterol ( 22.2 ± 1.3 mg/dl vs  8.8 ± 1.9 mg/dl, p = 0.01), LDL-cholesterol ( 15.2± 1.1 mg/dl vs  4.7 ± 1.2 mg/dl, p = 0.01), and HDL-cholesterol (6.2 ± 0.4 mg/dl vs  2.9 ± 1.2 mg/dl, p =0.01) modifications were better in non-G allele carriers. After intervention, the odds ratio (OR) of MS in non-carrier of G allele improved OR 0.48 (95%CI: 0.31–0.73; p = 0.02).Conclusions: G allele of rs490683 have a deleterious effect on dietary restrictions, body weight and metabolicresponse after a pMR diet.
PB Elsevier
SN 1056-8727
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/76176
UL https://uvadoc.uva.es/handle/10324/76176
LA eng
NO Journal of Diabetes and its Complications, 2025, vol. 39, n. 8, p. 109062
NO Producción Científica
DS UVaDOC
RD 23-jul-2025