RT info:eu-repo/semantics/doctoralThesis
T1 Papel de la célula δ-pancreática en la regulación de la homeostasis de la glucosa durante la gestación
A1 Goncalves RamÍrez, Arianna Carolina
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Glándulas endocrinas - Fisiología
K1 Transdifferentiation
K1 Transdiferenciación
K1 Pancreatic islet
K1 Islote pancreático
K1 Pregnancy
K1 Gestación
K1 pancreatic Delta cell
K1 Célula delta-pancreática
K1 32 Ciencias Médicas
AB Glucose metabolism is subject to complex regulation in the body, with various hormonal and enzymatic mechanisms working together to maintain balance. Among the hormones involved in this regulation, insulin (from β cells) plays a key role in decreasing postprandial glucose levels, while somatostatin (from δ cells) inhibits its secretion.During pregnancy, it is known that the levels of certain hormones increase, in which estrogens play a crucial role. It is believed that an increase in estrogen levels causes changes in the mass and function of β-cells to address insulin resistance, but there are no studies on the regulation of δ cells and the secretion of somatostatin during pregnancy.In this study, we found a decrease in the number of  δ-cells and an increase in bihormonal δ-cells expressing both PDX1 and Maf-A in pancreatic islets from an in vivo pregnancy model and after treatment with estradiol (E2). We also observed a decrease in somatostatin secretion, but an increase in the expression of both β-cell and δ-cell genes following acute treatment with E2. Additionally, we found that E2 decreases the levels of certain activators of somatostatin secretion, such as UCN3 and dynorphin, in both models. Therefore, we propose that this may reflect a transcriptomic deregulation due to an indirect effect of E2 on pancreatic δ-cells via depletion of their activators.In conclusion, this study provides evidence for the importance of pancreatic δ-cells and their ability to undergo cellular plasticity in response to the metabolic needs of the organism, helping to maintain intermediary metabolism homeostasis.
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/76249
UL https://uvadoc.uva.es/handle/10324/76249
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 24-ago-2025