RT info:eu-repo/semantics/article
T1 Towards an efficient methodology for the synthesis of functionalized dihydropyrans by silyl-Prins cyclization: access to truncated natural products
A1 Fernández Peña, Laura
A1 González-Andrés, Paula
A1 Barbero, Asunción
AB We herein present a selective methodology for the synthesis of disubstituted dihydropyrans by silyl-Prins cyclization of Z-vinylsilyl alcohols mediated by trimethylsilyl trifluoromethanesulfonate (TMSOTf). The reaction features broad substrate scope, short reaction times and ease of process scale-up. Moreover, to showcase the applicability of the proposed method, we also report a facile and linear synthesis of analogues of rhopaloic acid and natural doremox fragrance.
PB RSC
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/76255
UL https://uvadoc.uva.es/handle/10324/76255
LA eng
NO RSC Adv., 2024, 14, 707–711
DS UVaDOC
RD 26-jul-2025