RT info:eu-repo/semantics/article T1 The relationship between the eyelid status and contact lens discomfort A1 Valencia Nieto, Laura A1 López De La Rosa, Alberto A1 López Miguel, Alberto A1 González García, María Jesús K1 Eyelid K1 Lid margin K1 Contact lens K1 Discomfort K1 3201.09 Oftalmología AB Purpose: To study the relationship between eyelid alterations and the presence of contact lens discomfort (CLD) insoft contact lens (CL) wearers.Methods: One hundred thirty-seven CL wearers were included in this cross-sectional study. CLD symptoms werequantified by the Contact Lens Dry Eye Questionnaire (CLDEQ)-8. Participants were also classified consideringthe CLD effect on wearing time. Non-invasive tear break-up time was measured with the EasyTear® VIEW +Tearscope, tear film lipid layer thickness was assessed with the LipiView II interferometer, and lid margin pa-rameters, Meibomian gland morphology and function, and lid wiper epitheliopathy were evaluated using slit-lamp biomicroscopy (SL-D7, Topcon corp.). Correlations between symptoms and signs were analysed, andmultivariable regression models were performed.Results: Lid margin thickness (p = 0.07), Meibomian gland secretion quality (p = 0.02) and expressibility (p =0.09) showed a significant (p ≤ 0.1) simple association with the CLD effect classification, but only lid marginthickness reached statistical significance in the multivariable regression model [odds ratio (95 % confidenceinterval): 0.52 (0.30/0.87); p = 0.015]. No significant (p ≤ 0.05) simple linear association was found betweenthe CLDEQ-8 and any of the ocular parameters.Conclusions: The presence of mild CLD symptoms in soft CL wearers was not consistently associated with anyeyelid alteration, except for lid margin thickness. Future studies assessing the impact of lid margin thickness onCLD would be valuable. PB Elsevier SN 1367-0484 YR 2025 FD 2025 LK https://uvadoc.uva.es/handle/10324/76290 UL https://uvadoc.uva.es/handle/10324/76290 LA eng NO Contact Lens and Anterior Eye, 2025, p. 102439 NO Producción Científica DS UVaDOC RD 18-jul-2025