RT info:eu-repo/semantics/article
T1 Lower perturbational complexity index after transcranial magnetic stimulation in schizophrenia patients
A1 Molina Rodríguez, Vicente
A1 Fernández Linsenbarth, Ines
A1 Beño Ruiz De La Sierra, Rosa María
A1 Osorio Iriarte, María Emma
A1 Roig Herrero, Alejandro
A1 Arjona Valladares, Antonio
A1 Rodríguez González, Víctor
A1 Núñez Novo, Pablo
A1 Poza Crespo, Jesús
A1 Díez Revuelta, Álvaro
A1 Rodríguez Valbuena, Claudia
A1 Mijancos Martínez, Gema
A1 Bachiller Matarranz, Alejandro
A1 Mañanas, Miguel Angel
K1 Perturbational
K1 Complexity
K1 Schizophrenia
K1 Transcranial
K1 Stimulation
K1 32 Ciencias Médicas
AB Background: Informational integration and differentiation of the cortex can be tested by methods such as theperturbational complexity index (PCI) combined with TMS-induced activity perturbation. The PCI is obtained bystimulating the cortex with TMS and measuring the resulting spatiotemporal cortical responses with high-densityEEG.Methods: We have compared PCI between 26 patients with schizophrenia (15 males), 15 of them First Episode(FE) (7 males), and 22 healthy controls (12 males).Results: Values of PCI were significantly lower in patients with schizophrenia, as well as in FE considered alone.There was no significant relation between anomalous self-experiences or symptoms and PCI values in the pa-tients: PCI values were unrelated to treatment doses or illness duration.Conclusions: Our data suggest that spatiotemporal cortical responses to TMS pulses are reduced in patientsregarding variability or spatial extension, which could imply a lower capacity for sustaining informationalcomplexity.
PB Elsevier
SN 0278-5846
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/76709
UL https://uvadoc.uva.es/handle/10324/76709
LA eng
NO Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2025, vol. 137, p. 111254
NO Producción Científica
DS UVaDOC
RD 23-jul-2025