RT info:eu-repo/semantics/article
T1 Unbiased immunome characterisation correlates with COVID-19 mRNA vaccine failure in immunocompromised adults
A1 H-Vázquez, Juan
A1 Cal-Sabater, Paloma
A1 Arribas-Rodríguez, Elisa
A1 Fiz-López, Aida
A1 Perez-Segurado, Candido
A1 Martín-Muñoz, Álvaro
A1 De Prado, Ángel
A1 Perez Mazzali, Marina
A1 de Castro, Carolina G.
A1 del Hierro, Alejandro G.
A1 de la Fuente Graciani, Ignacio
A1 Pérez González, Sonia
A1 Gutiérrez, Sara
A1 Tellería, Pablo
A1 Novoa, Cristina
A1 Rojo Rello, Silvia
A1 Garcia-Blesa, Antonio
A1 Sedano, Rosa
A1 Martínez García, Ana María
A1 Garcinuño Pérez, Sonsoles
A1 Domínguez-Gil, Marta
A1 Hernán García, Cristina
A1 Guerra, Ma Mercedes
A1 Muñoz-Sánchez, Eduardo
A1 Barragan-Pérez, Cristina
A1 Diez Morales, Soraya
A1 Casazza Donnarumma, Oriana
A1 Ramos Pollo, Daniel
A1 Santamarta Solla, Natalia
A1 Álvarez Manzanares, Paula Ma
A1 Bravo, Sara
A1 García Alonso, Cristina
A1 Avendaño Fernández, Luis Alberto
A1 Gay Alonso, Jenifer
A1 Garrote, José A.
A1 Arranz, Eduardo
A1 Eiros, José María
A1 Rescalvo Santiago, Fernando
A1 Quevedo Villegas, Carolina
A1 Tamayo, Eduardo
A1 Orduña, Antonio
A1 Dueñas, Carlos
A1 Peñarrubia, María Jesús
A1 Cuesta-Sancho, Sara
A1 Montoya, María
A1 Bernardo, David
K1 Covid-19 (Enfermedad)
K1 Inmunología
K1 Computational cytometry
K1 Vaccine failure
K1 COVID-19
K1 Immunocompromised adult
K1 2412 Inmunología
AB Introduction: Coronavirus disease 2019 (COVID-19) affects the population unequally, with a greater impact on older and immunosuppressed people.Methods: Hence, we performed a prospective experimental cohort study to characterise the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in immune-compromised patients (older adults and oncohaematologic patients), compared with healthy counterparts, based on deep characterisation of the circulating immune cell subsets.Results and discussion: While acquired humoral and cellular memory did not predict subsequent infection 18 months after full vaccination, spectral and computational cytometry revealed several subsets within the CD8+ T-cells, B-cells, natural killer (NK) cells, monocytes and TEMRA Tγδ cells that were differentially expressed in individuals who were subsequently infected and not infected not just following immunisation, but also prior to vaccination. Of note, we found up to seven clusters within the TEMRA Tγδ cell population, with some of them being expanded and others decreased in subsequently infected individuals. Moreover, some of these cellular clusters were also related to COVID-19-induced hospitalisation in oncohaematologic patients. Therefore, we have identified a cellular signature that even before vaccination is related to COVID-19 vulnerability as opposed to the acquisition of cellular and/or humoral memory following vaccination with SARS-CoV-2 messenger RNA (mRNA) vaccines.
PB Frontiers in Immunology
SN 1664-3224
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/76933
UL https://uvadoc.uva.es/handle/10324/76933
LA eng
NO Frontiers in Immunology, November, 2024, Sec. Viral Immunology  Volume 15 - 2024 |
NO Producción Científica
DS UVaDOC
RD 03-ago-2025