RT info:eu-repo/semantics/article
T1 Embryonic Cerebrospinal Fluid Activates Neurogenesis of Neural Precursors within the Subventricular Zone of the Adult Mouse Brain
A1 Carnicero Gila, Estela María
A1 Alonso Revuelta, María Isabel
A1 Carretero Soto, Raquel
A1 Lamus Molina, José Francisco
A1 Moro Balbás, José Antonio
A1 Mano Bonín, Anibal de la
A1 Fernández Gómez, José María Fidel
A1 Gato Casado, Ángel Luis
K1 Neurorregeneración
K1 Embriología
AB Introduction: There is a nondeveloped neurogenic potentialin the adult mammalian brain, which could be the basis forneuroregenerative strategies. Many research efforts havebeen made to understand the control mechanisms whichregulate the transition from a neural precursor to a neuronin the adult brain. Embryonic cerebrospinal fluid (CSF) is acomplex fluid which has been shown to play a key role inneural precursor behavior during development, working asa powerful neurogenic inductor. We tested if the neurogenicproperties of embryonic CSF are able to increase the neurogenicactivity of neuronal precursors from the subventricularzone (SVZ) in the brains of adult mice. Results: Our resultsshow that mouse embryonic CSF significantly increasesthe neurogenic activity in precursor cells from adult brainSVZ. This intense neurogenic effect was specific for embryonicCSF and was not induced by adult CSF. Conclusions:Embryonic CSF is a powerful neurogenesis inductor in homologousneuronal precursors in the adult brain. This propertyof embryonic CSF could be a useful tool in neuroregenerationstrategies.
PB Karger
SN 1422-6405
YR 2013
FD 2013
LK http://uvadoc.uva.es/handle/10324/7748
UL http://uvadoc.uva.es/handle/10324/7748
LA eng
NO Cell  Tissues Organs, 2013, 198(5) 398-404
NO Producción Científica
DS UVaDOC
RD 27-nov-2024