RT info:eu-repo/semantics/doctoralThesis
T1 Estudio de la volumetría ventricular y de los polimorfismos del colágeno XVIII y acuaporina 4 y su relación con la hidrocefalia normotensiva idiopática
A1 Jiménez Zapata, Herbert Daniel
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Medicina Interna
K1 Normal pressure hydrocephalus
K1 Hidrocefalia normotensiva
K1 Cerebrospinal fluid
K1 Líquido cefalorraquídeo
K1 Polymorphism
K1 Polimorfismos
K1 Ventricle volumetry
K1 Volumetría ventricular
K1 32 Ciencias Médicas
AB Idiopathic normal pressure hydrocephalus is a clinical condition characterized by neurological symptoms associated with ventriculomegaly and normal intracranial pressure.It is one of the most common pathologies in neurosurgery, with a prevalence of 8.9% in patients over 80 years being one of the main causes of reversible neurological deterioration in the elderly.Its pathophysiology is not entirely clear, and new theories have emerged in the last decade, including impaired cerebral compliance, loss of pulsatility, and slowing of the glymphatic system. Within these theories, various blood-brain barrier proteins, such as aquaporin 4 and collagen XVIII, have gained significant importance.Currently, there are no diagnostic tests that allow us to accurately determine which patients with suspected idiopathic normal pressure hydrocephalus will benefit from CSF shunt placement. For that reason, nowadays selecting surgical candidates is a laborious and inexact process.In this thesis, we studied the relationship between ventricular size and postoperative outcome, observing that patients with normal pressure hydrocephalus who have smaller ventricles are more likely to improve. At the same time, we studied various polymorphisms of collagen XVIII and aquaporin 4, without observing differences between responders and non-responders.
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/77838
UL https://uvadoc.uva.es/handle/10324/77838
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 11-oct-2025