RT info:eu-repo/semantics/article
T1 The Carotid Body Does Not Mediate the Acute Ventilatory Effects of Leptin
A1 Olea, E.
A1 Ribeiro, M. J.
A1 Gallego-Martin, T.
A1 Yubero, S.
A1 Rigual, R.
A1 Masa, J. F.
A1 Obeso, A.
A1 Conde, S. V.
A1 Gonzalez, C.
AB Leptin is a hormone produced mostly in adipose tissue and playing a key role in the control of feeding and energy expenditure aiming to maintain a balance between food intake and metabolic activity. In recent years, it has been described that leptin might also contributes to control ventilation as the administration of the hormone reverses the hypoxia and hypercapnia commonly encountered in ob/ob mice which show absence of the functional hormone. In addition, it has been shown that the carotid body (CB) of the rat expresses leptin as well as the functional leptin-B receptor. Therefore, the possibility exists that the ventilatory effects of leptin are mediated by the CB chemoreceptors. In the experiments described below we confirm the stimulatory effect of leptin on ventilation, finding additionally that the CB does not mediate the instant to instant control of ventilation.
SN 0065-2598
YR 2015
FD 2015
LK https://uvadoc.uva.es/handle/10324/77940
UL https://uvadoc.uva.es/handle/10324/77940
LA eng
NO Adv Exp Med Biol. 2015, vol. 860, p. 379-85.
DS UVaDOC
RD 21-sep-2025