RT info:eu-repo/semantics/article
T1 Chronic intermittent hypoxia mimicking sleep apnoea increases spontaneous tumorigenesis in mice
A1 Gallego-Martin, Teresa
A1 Farré, Ramón
A1 Almendros, Isaac
A1 Gonzalez-Obeso, Elvira
A1 Obeso, Ana
AB This study provides the first evidence that severe intermittent hypoxia (IH), mimicking obstructive sleep apnoea (OSA), increases spontaneous tumorigenesis. Aged mice were exposed to normoxia, mild IH, or severe IH for three months. The group subjected to severe IH showed a significantly higher overall incidence of tumours and a marked increase in lung tumours compared to the control group. Mild IH had no significant effect. The findings suggest that OSA-related hypoxia may promote the development of new cancers, offering a new perspective for clinical data linking OSA to increased cancer incidence.
SN 0903-1936
YR 2017
FD 2017
LK https://uvadoc.uva.es/handle/10324/78025
UL https://uvadoc.uva.es/handle/10324/78025
LA eng
NO European Respiratory Journal, 2017, vol.49, issue 2, 1602111
DS UVaDOC
RD 21-oct-2025