RT info:eu-repo/semantics/article
T1 Organocatalytic Enantioselective Synthesis of Oxindole‐4‐Aminopyrazolone Derivatives via Mannich Reaction of 3‐Substituted Oxindoles With Pyrazolinone Ketimines
A1 Molinero, María E.
A1 Tejedor, Sandra
A1 Martín Maroto, Laura
A1 Maestro Fernández, Alicia
A1 Andrés García, José María
K1 Organocatálisis asimétrica
K1 Adición de Mannich
K1 Oxindol
K1 Cetiminas derivadas de pirazolinona
K1 Centros estereogénicos cuaternarios
AB The organocatalyzed Mannich reaction between pyrazolinone ketimines and 3-aryl-substituted oxindoles mediated by a hidroquinine-derived squaramide is reported. This method enables the synthesis of a diverse set of oxindole-4-aminopyrazolone derivatives bearing vicinal tetrasubstituted stereocenters, affording products in good yields (up to 95%), with excellent diastereoselectivity (> 20:1) and moderate enantioselectivity (up to 85:15 er) under mild conditions.
PB Wiley
SN 0022-152X
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/78449
UL https://uvadoc.uva.es/handle/10324/78449
LA eng
NO Journal of Heterocyclic Chemistry, 2025, vol. 62, p. 496-504.
NO Producción Científica
DS UVaDOC
RD 10-oct-2025