RT info:eu-repo/semantics/article
T1 Characterization and release modelling in ELR-based nanocomposite hydrogel loaded with polylactic acid for the implementation of a biomedical device
A1 Fernández Fernández, Julio
A1 Quintanilla Sierra, Luis
A1 Castaño, Óscar
A1 Roncada, Tosca
A1 Rodríguez Cabello, José Carlos
A1 Alonso Rodrigo, Matilde
A1 Engel, Elisabeth
A1 Santos García, María Mercedes
K1 Hydrogel
K1 Nanocomposite
K1 Elastin-like recombinamers
K1 Polylactic acid
K1 Early and sustained release
K1 2302 Bioquímica
AB Cardiac tissues are difficult to regenerate due to the low proliferative capacity of cardiomyocytes. A new ther-apeutic strategy for cardiac regenerative medicine could include a device capable of ensuring cell grafting,stimulating cardiac tissue regeneration, and serving as an appropriate scaffold for the controlled and sustainedrelease of lactate over time as an inducer of cardiomyocyte proliferation. An effective source of lactate couldconsist of the lactic acid polymer (PLA) itself, which generates free lactic acid during its degradation. In thiswork, we have developed a nanocomposite hydrogel for lactate release based on a biocompatible and biode-gradable matrix formed by elastin-like recombinamers cross-linked via click chemistry. Polylactic acid particleswere encapsulated in the matrix after these particles had been partially degraded to lactic acid through oxygenplasma treatment. In the first 48 h, an early and modulated release of free lactic acid from plasma-treated PLAdegradation is observed, and over longer periods, a sustained release of lactic acid produced by the hydrolyticdegradation of PLA under physiological conditions occurs. Lactate is available from the very beginning (“earlyrelease”), addressing the drawback of the slow degradation (by hydrolysis) of polylactic acid. Therefore, abiomedical device has been designed and implemented, formed by an ELR polymeric matrix as an analogue ofcardiac tissue, acting as a device for early, controlled, and sustained lactate release, with dosing at concentrationssimilar to those previously studied as suitable for promoting cardiomyocyte proliferation, showing promise for itsuse in the regeneration of infarcted cardiac tissue.
PB Elsevier
SN 0141-8130
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/78576
UL https://uvadoc.uva.es/handle/10324/78576
LA eng
NO International Journal of Biological Macromolecules, 2025, vol. 321, p.146552
NO Producción Científica
DS UVaDOC
RD 11-oct-2025