RT info:eu-repo/semantics/article
T1 Effect of transcranial magnetic pulses on cortical network connectivity in schizophrenia
A1 Molina Rodríguez, Vicente
A1 Ruiz Gómez, Saúl José
A1 Fernández Linsenbarth, Ines
A1 Beño Ruiz De La Sierra, Rosa María
A1 Osorio Iriarte, María Emma
A1 Roig, Alejandro
A1 Mijancos Martínez, Gema
A1 Rodríguez Valbuena, Claudia
A1 Bachiller Matarranz, Alejandro
A1 Mañanas, Miguel Ángel
A1 Díez Revuelta, Álvaro
K1 Schizophrenia
K1 Transcranial magnetic stimulation
K1 TMS-EEG
K1 TMS-evoked modulation
K1 Connectivity strength
K1 Cortical inhibition
K1 3211 Psiquiatría
AB Introduction: Transcranial magnetic stimulation (TMS) pulses applied to the cortex induce dynamic changes in brain network activity. These changes are useful for the in vivo study of functional connectivity, which may be characterized with the application of network parameters to the pre-stimulus (i. e., baseline) and the post- stimulus (i. e., response) of TMS-mediated electroencephalographic (EEG) recordings. These measures may be altered in schizophrenia, so we hypothesized a basal hyperactive network associated to hypomodulation with TMS in patients. Material and methods: Twenty-six schizophrenia patients and 26 healthy controls were subjected to TMS pulses during an EEG recording in order to assess the effect on connectivity strength (CS), a parameter summarizing the global EEG synchrony of the cortical network at baseline and its TMS-evoked modulation. Results: Patients showed a higher baseline CS in all bands except gamma. In controls, TMS increased CS in all bands, more notably on beta and gamma. In comparison to controls, patients showed a lower baseline-to- response multiband activity increase of CS, and significantly lower CS modulation values in the gamma band with TMS pulses. No relationships were found between these measures and antipsychotic dose or other clinical and cognitive variables. Conclusions: In the context of evidence supporting an inhibitory deficit in schizophrenia, these results may reflect the functional consequences of an inhibitory/GABAergic deficit in the cortex in this syndrome
PB Elsevier
SN 0278-5846
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/78651
UL https://uvadoc.uva.es/handle/10324/78651
LA eng
NO Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2025, vol. 141, p. 111471
NO Producción Científica
DS UVaDOC
RD 07-nov-2025