RT info:eu-repo/semantics/doctoralThesis
T1 Caracterización microbiana de las diarreas neonatales en ganado rumiante y porcino bajo el enfoque 'Una Salud'
A1 Cañete Reyes, Álvaro
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Ecología microbiana
K1 NGS
K1 One Health
K1 Una Salud
K1 Microbiota
K1 Neonatal diarrhea
K1 Diarreas Neonatales
K1 3109 Ciencias Veterinarias
AB Neonatal diarrea is one of the main causes of mortality in livestock, with mortality rates reaching up to 50% in some production systems. However, studying the bacterial microbiota involved faces the challenge of high regional variability, influenced by environmental factors, diet, geography, and management practices. Understanding these microbial profiles is crucial not only for animal health and farm management but also for public health, as several bacterial strains associated with livestock diarrhea have zoonotic potential, meaning they can be transmitted to humans directly or indirectly.Main objectives of the study:1.	Determine bacterial compositional profiles associated with neonatal diarrhea in Castilla y León.2.	Identify potential contamination routes by diarrheagenic bacteria in livestock farms.3.	Develop efficient control and management measures in farms affected by neonatal diarrhea.4.	Highlight the role of high-throughput sequencing in the identification and resolution of clinical cases related to neonatal diarrhea in livestock farms.Main conclusions:•	Neonatal diarrhea in sheep, pigs, goats, and cattle is characterized by the dominance of specific bacterial taxa, along with low species richness and evenness.•	The most abundant bacterial taxon in diarrheic neonatal animals is Escherichia-Shigella. In sheep, it is accompanied by Bacteroides, Lactobacillus, and Clostridium; in cattle, by Lactobacillus, Pseudomonas, Clostridium, and Bacteroides; and in pigs, by Fusobacterium and Clostridium.•	The “watery mouth” diarrheic syndrome, the main diarrheal condition in neonatal lambs, is defined by the abundance of Escherichia-Shigella and Clostridium, with Escherichia coli and Clostridium paraputrificum identified as dominant species.•	Farm management practices — particularly concerning bedding, milking systems, and water distribution.
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/78856
UL https://uvadoc.uva.es/handle/10324/78856
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 17-nov-2025