RT info:eu-repo/semantics/doctoralThesis T1 Sepsis atendida en la Unidad de Cuidados Intensivos. Epidemiología, mortalidad y fallo orgánico asociado tras la implantación de la Surviving Sepsis Campaign A1 Herrán Monge, Rubén A2 Universidad de Valladolid. Escuela de Doctorado K1 Sepsis K1 Sepsis K1 Septic shock K1 Shock séptico K1 Surviving sepsis campaign K1 3109.04 Medicina Interna AB Study conducted about the epidemiology of sepsis and septic shock through a prospective multicenter study (II GRECIA epidemiological study) carried out in several spanish intensive care units. Demographic, clinical and outcome variables were recorded, as well as adherence to the management recommendations of the international guidelines proposed by the Surviving Sepsis Campaign, relating the degree of compliance to the main mortality outcomes. An analysis of biomarkers is also carried out in blood samples from a cohort of septic patients included in the multicenter GENSEP study, also conducted in spanish intensive care units, to predict the development of Acute Respiratory Distress Syndrome and risk of mortality. Various predictive models built with several determinations of biomarkers panels combined with clinical variables and severity scores were obtained, with good discriminative capacity . YR 2025 FD 2025 LK https://uvadoc.uva.es/handle/10324/78863 UL https://uvadoc.uva.es/handle/10324/78863 LA spa NO Escuela de Doctorado DS UVaDOC RD 22-oct-2025