RT info:eu-repo/semantics/article
T1 Intereye asymmetry as a predictor of progression in patients with untreated keratoconus: findings from a longitudinal study
A1 Arnalich-Montiel, Francisco
A1 Kandel, Himal
A1 Lewis, Noni
A1 Chiong Hong, Sheng
A1 Downie, Nicholas
A1 Watson, Adam
A1 Abbondanza, Marco
A1 Watson, Stephanie
A1 Ortiz Toquero, Sara
K1 Keratoconus
K1 Progression
K1 Intereye
K1 Asymmetry
K1 3201.09 Oftalmología
K1 2209.15 Optometría
AB Purpose: The purpose of this study was to evaluate interocular predictors of progression in patients with untreated keratoconus.Methods: This is a multicenter longitudinal observational study with real-world data collected through the Save Sight Keratoconus Registry. Patients between the period of June 2000 and September 2022 were included in this study. Parameters such as patient age, sex, ocular history, visual acuity, K2, Max-K, and thinnest corneal thickness pachymetry (TCT) were analyzed.Results: There were 4342 untreated eyes from 2171 patients with keratoconus. A total of 333 patients showed progression of either Max-K, TCT, or both, whereas 1838 patients showed stable parameters. Factors associated with a higher incidence of progression in Max-K were younger baseline age (HR 0.96 per year older; 95% CI 0.95-0.98, P < 0.0001) and a higher baseline intereye asymmetry in Max-K (HR 1.02 per higher diopter; 95% CI 1.00-1.04, P = 0.04). A younger baseline age was the only predictor of progression in TCT (HR 0.97 per year older; 95% CI 0.95-0.99, P = 0.001).Conclusions: Age is the most significant predictor of progression for both corneal thinning and progression of Max-K. Interocular asymmetry in Max-K at baseline could be used as part of an algorithm for determining the risk of keratoconus progression. It is recommended that patients with higher interocular asymmetry in Max-K have a closer follow-up of both eyes as they are at a higher risk of progression.
PB Wolters Kluwer Health
SN 0277-3740
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/79422
UL https://uvadoc.uva.es/handle/10324/79422
LA eng
NO Cornea. 2025 Mar 1;44(3):337-341.
DS UVaDOC
RD 08-nov-2025