RT info:eu-repo/semantics/article
T1 Lipin-2 Reduces Proinflammatory Signaling Induced by Saturated Fatty Acids in Macrophages
A1 Valdearcos, Martín
A1 Esquinas, Esperanza
A1 Meana González, Clara
A1 Peña, Lucía
A1 Gil de Gómez, Luis
A1 Balsinde Rodríguez, Jesús
A1 Balboa García, María Ángeles
K1 Bioquímica
K1 Inmunología
K1 Biología molecular
K1 Genética médica
K1 Ácido graso
K1 Inflamación
K1 Lipotoxicidad
K1 Macrófagos
K1 Triglicéridos
K1 Lipina
K1 2302 Bioquímica
K1 2412 Inmunología
K1 3207 Patología
AB Lipin-2 is a member of the lipin family of enzymes, which are key effectors in the biosynthesis of lipids. Mutations in the human lipin-2 gene are associated with inflammatory-based disorders; however, the role of lipin-2 in cells of the immune system remains obscure. In this study, we have investigated the role of lipin-2 in the proinflammatory action of saturated fatty acids in murine and human macrophages. Depletion of lipin-2 promotes the increased expression of the proinflammatory genes Il6, Ccl2, and Tnfα, which depends on the overstimulation of the JNK1/c-Jun pathway by saturated fatty acids. In contrast, overexpression of lipin-2 reduces the release of proinflammatory factors. Metabolically, the absence of lipin-2 reduces the cellular content of triacylglycerol in saturated fatty acid-overloaded macrophages. Collectively, these studies demonstrate a protective role for lipin-2 in proinflammatory signaling mediated by saturated fatty acids that occurs concomitant with an enhanced cellular capacity for triacylglycerol synthesis. The data provide new insights into the role of lipin-2 in human and murine macrophage biology and may open new avenues for controlling the fatty acid-related low grade inflammation that constitutes the sine qua non of obesity and associated metabolic disorders.
PB Elsevier
SN 0021-9258
YR 2012
FD 2012
LK https://uvadoc.uva.es/handle/10324/79487
UL https://uvadoc.uva.es/handle/10324/79487
LA eng
NO The Journal of Biological Chemistry, Mar 2012, 287(14):10894-904
NO Producción Científica
DS UVaDOC
RD 11-mar-2026