RT info:eu-repo/semantics/article
T1 Lipin-2 Reduces Proinflammatory Signaling Induced by Saturated Fatty Acids in Macrophages
A1 Valdearcos, Martín
A1 Esquinas, Esperanza
A1 Meana, Clara
A1 Peña, Lucía
A1 Gil-de-Gómez, Luis
A1 Balsinde, Jesús
A1 Balboa, María A.
AB Lipin-2 is a member of the lipin family of enzymes, which are key effectors in the biosynthesis of lipids. Mutations in the human lipin-2 gene are associated with inflammatory-based disorders; however, the role of lipin-2 in cells of the immune system remains obscure. In this study, we have investigated the role of lipin-2 in the proinflammatory action of saturated fatty acids in murine and human macrophages. Depletion of lipin-2 promotes the increased expression of the proinflammatory genes Il6, Ccl2, and Tnfα, which depends on the overstimulation of the JNK1/c-Jun pathway by saturated fatty acids. In contrast, overexpression of lipin-2 reduces the release of proinflammatory factors. Metabolically, the absence of lipin-2 reduces the cellular content of triacylglycerol in saturated fatty acid-overloaded macrophages. Collectively, these studies demonstrate a protective role for lipin-2 in proinflammatory signaling mediated by saturated fatty acids that occurs concomitant with an enhanced cellular capacity for triacylglycerol synthesis. The data provide new insights into the role of lipin-2 in human and murine macrophage biology and may open new avenues for controlling the fatty acid-related low grade inflammation that constitutes the sine qua non of obesity and associated metabolic disorders.
PB Elsevier
SN 0021-9258
YR 2012
FD 2012
LK https://uvadoc.uva.es/handle/10324/79487
UL https://uvadoc.uva.es/handle/10324/79487
LA spa
NO The Journal of Biological Chemistry, Mar 2012, 287(14):10894-904
DS UVaDOC
RD 09-nov-2025