RT info:eu-repo/semantics/article
T1 Correlation between endogenous polyamines in human cardiac tissues and clinical parameters in patients with heart failure
A1 Meana González, Clara
A1 Rubín, José Manuel
A1 Bordallo, Carmen
A1 Suárez, Lorena
A1 Bordallo, Javier
A1 Sánchez, Manuel
K1 Bioquímica
K1 Cardiología
K1 Fisiología humana
K1 Patología clínica
K1 corazón
K1 aurículas
K1 ornitina descarboxilasa
K1 N1-acetilpoliamina oxidasa
K1 poliaminas
K1 putrescina
K1 espermidina
K1 espermina
K1 AMP cíclico
K1 insuficiencia cardíaca
K1 2302 Bioquímica
K1 3205 Medicina Interna
K1 2411 Fisiología Humana
AB Polyamines contribute to several physiological and pathological processes, including cardiac hypertrophy in experimental animals. This involves an increase in ornithine decarboxylase (ODC) activity and intracellular polyamines associated with cyclic adenosine monophosphate (cAMP) increases. The aim of the study was to establish the role of these in the human heart in living patients. For this, polyamines (by high performance liquid chromatography) and the activity of ODC and N(1)-acetylpolyamine oxidases (APAO) were determined in the right atrial appendage of 17 patients undergoing extracorporeal circulation to correlate with clinical parameters. There existed enzymatic activity associated with the homeostasis of polyamines. Left atria size was positively associated with ODC (r = 0.661, P = 0.027) and negatively with APAO-N(1) -acetylspermine (r = -0.769, P = 0.026), suggesting that increased levels of polyamines are associated with left atrial hemodynamic overload. Left ventricular ejection fraction (LVEF) and heart rate were positively associated with spermidine (r = 0.690, P = 0.003; r = 0.590, P = 0.021) and negatively with N(1)-acetylspermidine (r = -0.554, P = 0.032; r = -0.644, P = 0.018). LVEF was negatively correlated with cAMP levels (r = -0.835, P = 0.001) and with cAMP/ODC (r = -0.794, P = 0.011), cAMP/spermidine (r = -0.813, P = 0.001) and cAMP/spermine (r = -0.747, P = 0.003) ratios. Abnormal LVEF patients showed decreased ODC activity and spermidine, and increased N(1) -acetylspermidine, and cAMP. Spermine decreased in congestive heart failure patients. The trace amine isoamylamine negatively correlated with septal wall thickness (r = -0.634, P = 0.008) and was increased in cardiac heart failure. The results indicated that modifications in polyamine homeostasis might be associated with cardiac function and remodelling. Increased cAMP might have a deleterious effect on function. Further studies should confirm these findings and the involvement of polyamines in different stages of heart failure.
PB Wiley
SN 1582-1838
YR 2015
FD 2015
LK https://uvadoc.uva.es/handle/10324/79490
UL https://uvadoc.uva.es/handle/10324/79490
LA eng
NO Journal of Cellular and Molecular Medicine, Feb 2016, vol. 20, n. 2, p. 302-12
NO Producción Científica
DS UVaDOC
RD 23-mar-2026