RT info:eu-repo/semantics/article
T1 Foamy Monocytes Are Enriched in cis -7-Hexadecenoic Fatty Acid (16:1n-9), a Possible Biomarker for Early Detection of Cardiovascular Disease
A1 Guijas, Carlos
A1 Meana, Clara
A1 Astudillo, Alma M.
A1 Balboa, María A.
A1 Balsinde, Jesús
AB Human monocytes respond to arachidonic acid, a secretory product of endothelial cells, by activating the de novo pathway of fatty acid biosynthesis, resulting in the acquisition of a foamy phenotype due to accumulation of cytoplasmic lipid droplets. Recruitment of foamy monocytes to endothelium is a key step in the formation of atherosclerotic plaques. Here we describe that lipid droplets of foamy monocytes are enriched in a rather uncommon fatty acid, cis-7-hexadecenoic acid (16:1n-9), a positional isomer of palmitoleic acid. 16:1n-9 was found to possess an anti-inflammatory activity both in vitro and in vivo that is comparable with that of omega-3 fatty acids and clearly distinguishable from the effects of palmitoleic acid. Selective accumulation in neutral lipids of phagocytic cells of an uncommon fatty acid reveals an early phenotypic change that may provide a biomarker of proatherogenicity, and a potential target for intervention in the early stages of cardiovascular disease.
SN 2451-9456
YR 2016
FD 2016
LK https://uvadoc.uva.es/handle/10324/79491
UL https://uvadoc.uva.es/handle/10324/79491
LA spa
NO Cell Chemical Biology, Jun 2016, vol. 23, n. 6, p. 689-99
DS UVaDOC
RD 09-nov-2025