RT info:eu-repo/semantics/article
T1 The role of lipins in innate immunity and inflammation
A1 Balboa, María A.
A1 Pablo Herranz, Nagore de
A1 Meana González, Clara
A1 Balsinde Rodríguez, Jesús
K1 Bioquímica
K1 Inmunología
K1 Genética médica
K1 Biología celular
K1 Lipina
K1 Macrófagos
K1 Inflamación
K1 Diacilglicerol
K1 Ácido fosfatídico
K1 2302 Bioquímica
K1 2412 Inmunología
K1 2407 Biología Celular
AB Lipins are phosphatidic acid phosphatase enzymes whose cellular function in regulating lipid metabolism has been known for decades, particularly in metabolically active tissues such as adipose tissue or liver. In recent years evidence is accumulating for key regulatory roles of the lipin family in innate immune cells. Lipins may help regulate signaling through relevant immune receptors such as Toll-like receptors, and are also integral part of the cellular machinery for lipid storage in these cells, thereby modulating certain inflammatory processes. Mutations in genes that encode for members of this family produce autoinflammatory hereditary diseases or diseases with an important inflammatory component in humans. In this review we summarize recent findings on the role of lipins in cells of the innate immune system and in the onset and progress of inflammatory processes.
PB Elsevier
SN 1388-1981
YR 2019
FD 2019
LK https://uvadoc.uva.es/handle/10324/79594
UL https://uvadoc.uva.es/handle/10324/79594
LA eng
NO Biochim Biophys Acta Mol Cell Biol Lipids, Oct 2019, vol. 864, n. 10, p. 1328-1337
NO Producción Científica
DS UVaDOC
RD 26-feb-2026