RT info:eu-repo/semantics/doctoralThesis
T1 Acoplamientos C-C y C-N en complejos metálicos de Ni(II) y Cu(I) con ligandos isocianuro
A1 Carmen Rodríguez, Clara del
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Química Inorgánica
K1 Isocyanide
K1 Isocianuro - complejos
K1 2303 Química Inorgánica
AB This Doctoral Thesis focuses on the study of Ni(II) and Cu(I) metal complexes with isocyanide ligands. Chapters I and II are focused on the reactivity of these isocyanides by reaction with different nucleophiles. In Chapter I, they have been used for the synthesis of acyclic diaminocarbenes (ADCs) by reaction with secondary amines, obtaining air-stable Ni(II) complexes with ADCs. The alkyldithiophosphate ligands stabilize the final complexes. When these reactions are carried out in basic medium, isocyanide coupling takes place in the Ni(II) coordination sphere (Chapter II). In addition, obtaining discrete Ni complexes with coupled isocyanides has allowed us to further investigate the procedure for the synthesis of polyisocyanides, finding that the key intermediate in the process is a complex with a formamidinyl ligand and not an acyclic carbene, as it was previously reported. Isocyanide couplings can be carried out by using heterocyclic nucleophiles, giving rise to more complex structures which, in addition, have potential pharmacological activity. Finally, in Chapter III, isocyanide ligands have been used to stabilize Cu(I) metallo-supramolecular structures, which are built using triazole ligands, Cu(I) and the isocyanide ligands themselves as building blocks. In this way, it has been possible to synthesise bowl-shaped metal complexes, which maintain their structure in solution and show potential properties in molecular recognition. We also synthezised different complexes with cage structure, which show different properties depending on the metal encapsulated inside.
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/80061
UL https://uvadoc.uva.es/handle/10324/80061
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 25-nov-2025