RT info:eu-repo/semantics/article
T1 Synthesis of chiral α-alkynyl-α-hydroxyamides by enantioselective alkynylation of α-keto amides
A1 Prieto, Elena
A1 Andrés Juan, Celia
A1 Nieto Román, Francisco Javier
K1 Química Orgánica Sintética
K1 Catálisis Asimétrica
K1 Química Organometálica
K1 2306 Química Orgánica
K1 2301 Química Analítica
AB The α-hydroxyamide moiety is an important structural component in a wide variety of biologically activecompounds and natural products. Herein, we describe a highly efficient and practical approach towardschiral quaternary α-alkynyl-α-hydroxyamides by Me2Zn-mediated addition of terminal alkynes to α-ketoamides. The desired products are obtained in good yields and enantioselectivities with broad substrateand reagent scopes.
PB The Royal Society of Chemistry
SN 1477-0520
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/80120
UL https://uvadoc.uva.es/handle/10324/80120
LA spa
NO Organic & Biomolecular Chemistry, 2025, vol. 23, p 10596-10605.
NO Producción Científica
DS UVaDOC
RD 12-ene-2026