RT info:eu-repo/semantics/article
T1 Synthesis of chiral α-alkynyl-α-hydroxyamides by enantioselective alkynylation of α-keto amides
A1 Prieto, Elena
A1 Andrés, Celia
A1 Nieto, Javier
AB The α-hydroxyamide moiety is an important structural component in a wide variety of biologically activecompounds and natural products. Herein, we describe a highly efficient and practical approach towardschiral quaternary α-alkynyl-α-hydroxyamides by Me2Zn-mediated addition of terminal alkynes to α-ketoamides. The desired products are obtained in good yields and enantioselectivities with broad substrateand reagent scopes.
PB The Royal Society of Chemistry
SN 1477-0520
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/80120
UL https://uvadoc.uva.es/handle/10324/80120
LA spa
NO Organic & Biomolecular Chemistry, 2025, vol. 23, p 10596-10605.
DS UVaDOC
RD 27-nov-2025