RT info:eu-repo/semantics/article
T1 Corollary Discharge Dysfunction as a Possible Substrate of Anomalous Self-experiences in Schizophrenia
A1 Beño Ruiz De La Sierra, Rosa María
A1 Arjona Valladares, Antonio
A1 Hernández García, Marta Saray
A1 Fernández Linsenbarth, Ines
A1 Díez Revuelta, Álvaro
A1 Fondevila Estévez, Sabela
A1 Castaño, Carolina
A1 Muñoz, Francisco
A1 Sanz Fuentenebro, Javier
A1 Roig Herrero, Alejandro
A1 Molina Rodríguez, Vicente
AB Background and hypothesis: Corollary discharge mechanism suppresses the conscious auditory sensory perception of self-generated speech and attenuates electrophysiological markers such as the auditory N1 Event-Related Potential (ERP) during Electroencephalographic (EEG) recordings. This phenomenon contributes to self-identification and seems to be altered in people with schizophrenia. Therefore, its alteration could be related to the anomalous self-experiences (ASEs) frequently found in these patients.Study design: To analyze corollary discharge dysfunction as a possible substrate of ASEs, we recorded EEG ERP from 43 participants with schizophrenia and 43 healthy controls and scored ASEs with the 'Inventory of Psychotic-Like Anomalous Self-Experiences' (IPASE). Positive and negative symptoms were also scored with the 'Positive and Negative Syndrome Scale for Schizophrenia' (PANSS) and with the 'Brief Negative Symptom Scale' (BNSS) respectively. The N1 components were elicited by two task conditions: (1) concurrent listening to self-pronounced vowels (talk condition) and (2) subsequent non-concurrent listening to the same previously self-uttered vowels (listen condition).Study results: The amplitude of the N1 component elicited by the talk condition was lower compared to the listen condition in people with schizophrenia and healthy controls. However, the difference in N1 amplitude between both conditions was significantly higher in controls than in schizophrenia patients. The values of these differences in patients correlated significantly and negatively with the IPASE, PANSS, and BNSS scores.Conclusions: These results corroborate previous data relating auditory N1 ERP amplitude with altered corollary discharge mechanisms in schizophrenia and support corollary discharge dysfunction as a possible underpinning of ASEs in this illness.
PB Oxford Journals
SN 0586-7614
YR 2024
FD 2024
LK https://uvadoc.uva.es/handle/10324/80229
UL https://uvadoc.uva.es/handle/10324/80229
LA spa
NO Schizophr Bull. 2024 Aug 27;50(5):1137-1146.
DS UVaDOC
RD 04-mar-2026