RT info:eu-repo/semantics/article
T1 The Lipocalin Apolipoprotein D Functional Portrait: A Systematic Review
A1 Sánchez Romero, Diego
A1 Ganfornina Álvarez, María Dolores
AB Apolipoprotein D is a chordate gene early originated in the Lipocalin protein family. Amongother features, regulation of its expression in a wide variety of disease conditions inhumans, as apparently unrelated as neurodegeneration or breast cancer, have calledfor attention on this gene. Also, its presence in different tissues, from blood to brain,and different subcellular locations, from HDL lipoparticles to the interior of lysosomesor the surface of extracellular vesicles, poses an interesting challenge in deciphering itsphysiological function: Is ApoD a moonlighting protein, serving different roles in differentcellular compartments, tissues, or organisms? Or does it have a unique biochemicalmechanism of action that accounts for such apparently diverse roles in differentphysiological situations? To answer these questions, we have performed a systematicreview of all primary publications where ApoD properties have been investigated inchordates. We conclude that ApoD ligand binding in the Lipocalin pocket, combinedwith an antioxidant activity performed at the rim of the pocket are properties sufficient toexplain ApoD association with different lipid-based structures, where its physiologicalfunction is better described as lipid-management than by long-range lipid-transport.Controlling the redox state of these lipid structures in particular subcellular locationsor extracellular structures, ApoD is able to modulate an enormous array of apparentlydiverse processes in the organism, both in health and disease. The new picture emergingfrom these data should help to put the physiological role of ApoD in new contexts andto inspire well-focused future research.
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/80439
UL https://uvadoc.uva.es/handle/10324/80439
LA spa
NO Front Physiol. 2021 Oct 7;12:738991
NO Producción Científica
DS UVaDOC
RD 29-mar-2026