RT info:eu-repo/semantics/article
T1 Quantitative Assessment of Emphysema Severity in Histological Lung Analysis
A1 Marcos Martín, José Víctor
A1 Muñoz Barrutia, Arrate
A1 Ortiz-de-Solórzano, Carlos
A1 Cristóbal, Gabriel
AB Emphysema is a characteristic component of chronic obstructive pulmonarydisease (COPD), which has been pointed out as one of the main causes of mortalityfor the next years. Animal models of emphysema are employed to study the evolutionof this disease as well as the effect of treatments. In this context, measures such asthe mean linear intercept (Lm) and the equivalent diameter (d) have been proposed toquantify the airspace enlargement associated with emphysematous lesions in histologicalsections. The parameter D2, which relates the second and the third momentsof the variable d, has recently shown to be a robust descriptor of airspace enlargement.However, the value of D2 does not provide a direct evaluation of emphysemaseverity. In our research, we suggest a Bayesian approach to map D2 onto a novel emphysemaseverity index (SI) reflecting the probability for a lung patch to be emphysematous.Additionally, an image segmentation procedure was developed to computethe severity map of a lung section using the SI function. Severity maps correspondingto 54 lung sections from control mice, mice induced with mild emphysema and miceinduced with severe emphysema were computed, revealing differences between thedistribution of SI in the three groups. The proposed methodology could assist in thequantification of emphysema in animal models.
PB Springer
SN 0090-6964
YR 2015
FD 2015
LK https://uvadoc.uva.es/handle/10324/80470
UL https://uvadoc.uva.es/handle/10324/80470
LA spa
NO Marcos, J.V., Muñoz-Barrutia, A., Ortiz-de-Solórzano, C. and Cristóbal, G., 2015. Quantitative assessment of emphysema severity in histological lung analysis. Annals of Biomedical Engineering, 43(10), pp.2515-2529
DS UVaDOC
RD 13-dic-2025