RT info:eu-repo/semantics/article
T1 Gene Co-Expression Networks Offer New Perspectives on Sepsis Pathophysiology
A1 Martínez-Paz, Pedro
A1 Gomez-Pilar, Javier
A1 Martín-Fernández, Marta
A1 Ceballos, Francisco C.
A1 Gómez-Sánchez, Esther
A1 Hornero, Roberto
A1 Tamayo, Eduardo
AB Sepsis is among the most common causes of death in intensive care units. Septic shock is a type of circulatory shock that shows signs and symptoms that are similar to non-septic shock. Despite the impact of shock on patients and the economic burden, knowledge of the pathophysiology of septic shock is scarce. In this context, weighted gene co-expression network analysis can help to elucidate the molecular mechanisms of this condition. The gene expression dataset used in this study was downloaded from the Gene Expression Omnibus, which contains 80 patients with septic shock, 33 patients with non-septic shock, and 15 healthy controls. Our novel analysis revealed five gene modules specific for patients with septic shock and three specific gene modules for patients with non-septic shock. Interestingly, genes related to septic shock were mainly involved in the immune system and endothelial cells, while genes related to non-septic shock were primarily associated with endothelial cells. Together, the results revealed the specificity of the genes related to the immune system in septic shock. The novel approach developed here showed its potential to identify critical pathways for the occurrence and progression of these conditions while offering new treatment strategies and effective therapies.
PB IEEE
SN 1545-5963
YR 2023
FD 2023-11
LK https://uvadoc.uva.es/handle/10324/80517
UL https://uvadoc.uva.es/handle/10324/80517
LA spa
NO IEEE/ACM Trans Comput Biol Bioinform. 2023 Nov-Dec;20(6):3660-3668.
DS UVaDOC
RD 13-dic-2025