RT info:eu-repo/semantics/article
T1 Impact of pesticide use on gut microbiota and health: a sys-tematic review of findings in humans and animal models
A1 Osa Subtil, Iria
A1 Romero Rosales, Teolincacihuatl
A1 de Dios Duarte, María José
K1 Pesticide exposure
K1 human health
K1 gut microbiome
K1 metabolic disorders
K1 inflammation
K1 neurodevelopmental effects
K1 immune disorders
AB (1) Background/objective: The intensive use of pesticides in modern agriculture has raised growing concerns about their potential adverse effects on human health. Exposure to these compounds has been linked to a variety of negative outcomes. This study aims to evaluate and synthesize the available scientific evidence on the impact of pesticide exposure in agricultural production on human health. It will integrate results from experimental and observational studies conducted on ani-mals and humans. (3) Results: Findings show that exposure, particularly during the prenatal period, is associated with multisystemic alterations affecting fetal de-velopment, metabolism, the immune system, the nervous system, and the gut mi-crobiome. Evidence from animal model studies complements human data, providing insight into the underlying biological mechanisms, such as oxidative stress, liver dysfunction, alterations in hormonal signaling and activation of the inflammatory response. (4) Conclusions: Public health strategies must be imple-mented to reduce pesticide exposure, strengthen environmental and mater-nal-child surveillance, and promote research into the modulation of the gut micro-biome and systemic inflammation. This will help to prevent and mitigate the met-abolic, immunological, and neurodevelopmental effects associated with these compounds.
SN 2039-4713
YR 2025
FD 2025
LK https://uvadoc.uva.es/handle/10324/80690
UL https://uvadoc.uva.es/handle/10324/80690
LA eng
NO Journal of Xenobiotics
NO Producción Científica
DS UVaDOC
RD 11-ene-2026